J
Jessica Giehrl-Schwab
Publications - 3
Citations - 42
Jessica Giehrl-Schwab is an academic researcher. The author has contributed to research in topics: Proteome & Cas9. The author has an hindex of 2, co-authored 2 publications receiving 13 citations.
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Journal ArticleDOI
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion.
Gianluca Luigi Russo,Giovanna Sonsalla,Poornemaa Natarajan,Christopher T. Breunig,Giorgia Bulli,Juliane Merl-Pham,Sabine Schmitt,Jessica Giehrl-Schwab,Florian Giesert,Martin Jastroch,Hans Zischka,Wolfgang Wurst,Stefan H. Stricker,Stefanie M. Hauck,Giacomo Masserdotti,Magdalena Götz +15 more
TL;DR: The comprehensive mitochondrial proteome of cortical astrocytes and neurons is determined, identifying about 150 significantly enriched mitochondrial proteins for each cell type, including transporters, metabolic enzymes, and cell-type-specific antioxidants.
Journal ArticleDOI
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Jessica Giehrl-Schwab,Florian Giesert,Benedict Samuel Rauser,Chu Lan Lao,Sina Hembach,Sandrine Lefort,Ignacio L. Ibarra,Christina Koupourtidou,Malte D Luecken,Dong-Jiunn Jeffery Truong,Judith Fischer-Sternjak,Giacomo Masserdotti,Nilima Prakash,Jovica Ninkovic,Sabine M. Hölter,Daniela Vogt-Weisenhorn,Fabian J. Theis,Magdalena Götz,Wolfgang Wurst +18 more
TL;DR: A knock‐in mouse line carrying a dual dCas9 transactivator system allowing the conditional in vivo activation of endogenous genes and an AAV‐dCAS approach to enable an alternative route for clinical therapies of Parkinson's disease suggest a novel intervention strategy beyond the restoration of dopamine levels.
Journal ArticleDOI
A Customizable Protocol for String Assembly gRNA Cloning (STAgR).
Christopher T. Breunig,Andrea M. Neuner,Jessica Giehrl-Schwab,Wolfgang Wurst,Magdalena Götz,Stefan H. Stricker +5 more
TL;DR: This work presents a customizable protocol for string assembly gRNA cloning (STAgR), a method that allows the simple, fast and efficient generation of multiplexed gRNA expression vectors in a single cloning step.