Sabine M. Hölter

TL;DR: In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional FOXP2 allele, it is found that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity, suggesting that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans.

TL;DR: It is found that loss of cytosine‐5 RNA methylation increases the angiogenin‐mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5′ tRNA‐derived small RNA fragments, and failure in NSun2‐mediated tRNA methylation contributes to human diseases via stress‐induced RNA cleavage.

TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.

TL;DR: While rapamycin did extend lifespan, it ameliorated few studied aging phenotypes and had similar effects on many of these traits in young animals, indicating that these effects were not due to a modulation of aging, but rather related to aging-independent drug effects.

TL;DR: The alcohol deprivation effect outlasts very long abstinence phases, which indicates the persistence of a drug memory for alcohol in animal models of long-term, free-choice, alcohol self-administration followed by alcohol deprivation phases.