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Jessica Strömberg

Researcher at Umeå University

Publications -  18
Citations -  761

Jessica Strömberg is an academic researcher from Umeå University. The author has contributed to research in topics: Allopregnanolone & Neuroactive steroid. The author has an hindex of 9, co-authored 18 publications receiving 647 citations.

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Allopregnanolone and mood disorders.

TL;DR: Findings suggest that negative mood symptoms in women with PMDD are caused by the paradoxical effect of allopregnanolone mediated via the GABA-A receptor.
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Pathogenesis in menstrual cycle-linked CNS disorders.

TL;DR: Animal and human studies show that GABA‐A receptor‐positive modulators like barbiturates, benzodiazepines, alcohol, and allopregnanolone have a bimodal effect, which can induce adverse emotional reactions in up to 20% of individuals and induce tolerance to themselves and similar substances.
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Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons.

TL;DR: Some women have negative mood symptoms, caused by progestagens in hormonal contraceptives or sequential hormone therapy or by progesterone in the luteal phase of the menstrual cycle as mentioned in this paper.
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Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3β-hydroxy-5α-pregnan-20-one (isoallopregnanolone)

TL;DR: Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnane-20-one (isoallopreg Nanolone)
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Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the γ-aminobutyric acid-A receptor

TL;DR: The results showed that steroids released during stress interact with each other and GABA in the GABA system, and both cortisol and cortisone metabolites reduce GABA‐mediated chloride ion uptake.