J
Jessie S. Jeon
Researcher at KAIST
Publications - 67
Citations - 3637
Jessie S. Jeon is an academic researcher from KAIST. The author has contributed to research in topics: Extravasation & Cancer cell. The author has an hindex of 19, co-authored 57 publications receiving 2904 citations. Previous affiliations of Jessie S. Jeon include Massachusetts Institute of Technology.
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Journal ArticleDOI
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
Jessie S. Jeon,Simone Bersini,Mara Gilardi,Gabriele Dubini,Joseph L. Charest,Matteo Moretti,Roger D. Kamm +6 more
TL;DR: A microfluidic 3D in vitro model is developed to analyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells.
Journal ArticleDOI
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
Yoojin Shin,Sewoon Han,Jessie S. Jeon,Kyoko Yamamoto,Ioannis K. Zervantonakis,Ryo Sudo,Roger D. Kamm,Seok Chung +7 more
TL;DR: In this article, a simple but robust microfluidic assay combining three-dimensional and two-dimensional (2D) cell culture is described, which can be applied to multiple cell types interacting over distances of <1 mm, thereby replicating many aspects of the in vivo microenvironment.
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
Yoojin Shin,Sewoon Han,Jessie S. Jeon,Kyoko Yamamoto,Ioannis K. Zervantonakis,Ryo Sudo,Roger D. Kamm,Seok Chung +7 more
TL;DR: This protocol describes a simple but robust microfluidic assay combining three-dimensional and two-dimensional cell culture, used to study cell survival, proliferation, migration, morphogenesis and differentiation under controlled conditions.
Journal ArticleDOI
A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone
Simone Bersini,Jessie S. Jeon,Gabriele Dubini,Chiara Arrigoni,Seok Chung,Joseph L. Charest,Matteo Moretti,Roger D. Kamm +7 more
TL;DR: This study provides novel 3D in vitro quantitative data on extravasation and micrometastasis generation of breast cancer cells within a bone-like microenvironment and demonstrates the potential value of microfluidic systems to better understand cancer biology and screen for new therapeutics.
Journal ArticleDOI
Mechanisms of tumor cell extravasation in an in vitro microvascular network platform
TL;DR: In this paper, the authors used a microfluidic platform to study tumor cell extravasation from in vitro microvascular networks formed via vasculogenesis, and demonstrated tight endothelial cell-cell junctions, basement membrane deposition and physiological values of vessel permeability.