Y
Yoojin Shin
Researcher at Massachusetts Institute of Technology
Publications - 43
Citations - 3109
Yoojin Shin is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Extracellular matrix & Neural stem cell. The author has an hindex of 20, co-authored 43 publications receiving 2302 citations. Previous affiliations of Yoojin Shin include Korea University.
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Journal ArticleDOI
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
Yoojin Shin,Sewoon Han,Jessie S. Jeon,Kyoko Yamamoto,Ioannis K. Zervantonakis,Ryo Sudo,Roger D. Kamm,Seok Chung +7 more
TL;DR: In this article, a simple but robust microfluidic assay combining three-dimensional and two-dimensional (2D) cell culture is described, which can be applied to multiple cell types interacting over distances of <1 mm, thereby replicating many aspects of the in vivo microenvironment.
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
Yoojin Shin,Sewoon Han,Jessie S. Jeon,Kyoko Yamamoto,Ioannis K. Zervantonakis,Ryo Sudo,Roger D. Kamm,Seok Chung +7 more
TL;DR: This protocol describes a simple but robust microfluidic assay combining three-dimensional and two-dimensional cell culture, used to study cell survival, proliferation, migration, morphogenesis and differentiation under controlled conditions.
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3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
Marco Campisi,Yoojin Shin,Tatsuya Osaki,Cynthia Hajal,Valeria Chiono,Roger D. Kamm,Roger D. Kamm +6 more
TL;DR: A robust and physiologically relevant BBB microvascular model offers an innovative and valuable platform for drug discovery to predict neuro-therapeutic transport efficacy in pre-clinical applications as well as recapitulate patient-specific and pathological neurovascular functions in neurodegenerative disease.
Journal ArticleDOI
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics
TL;DR: In this article, the authors describe an in vitro model of the human microcirculation with the potential to recapitulate discrete steps of early metastatic seeding, including arrest, transendothelial migration and early micrometastases formation.
Journal ArticleDOI
Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
TL;DR: A microfluidic chip-based tumor tissue culture model that integrates 3D tumor spheroids (TSs) with CAF in proximity within a hydrogel scaffold is presented and the reciprocal interaction between TSs and fibroblasts is demonstrated in the authors' 7-channel microfluidity chip.