J
Ji Hyeon Oh
Researcher at Catholic University of Korea
Publications - 12
Citations - 840
Ji Hyeon Oh is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Mesenchymal stem cell & Glioma. The author has an hindex of 8, co-authored 8 publications receiving 798 citations.
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Journal ArticleDOI
Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells against Intracranial Glioma
Seong Muk Kim,Jung Yeon Lim,Sang In Park,Chang Hyun Jeong,Ji Hyeon Oh,Moonsup Jeong,Wonil Oh,Sang Hoon Park,Young-Chul Sung,Sin-Soo Jeun +9 more
TL;DR: In vivo efficacy experiments showed that intratumoral injection of engineered UCB-MSCs (MSCs-stTRAIL) significantly inhibited tumor growth and prolonged the survival of glioma-bearing mice compared with controls, suggesting that human UCB -MSCs have potential use as effective delivery vehicles for therapeutic genes in the treatment of intracranialglioma.
Journal ArticleDOI
Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways.
Jung Yeon Lim,Sang In Park,Ji Hyeon Oh,Seong Muk Kim,Chang Hyun Jeong,Jin Ae Jun,Kwan-Sung Lee,Wonil Oh,Jaekwon Lee,Sin-Soo Jeun +9 more
TL;DR: MAPK/ERK‐dependent p35 up‐regulation and MAPK/ERG‐dependent and PI3K/Akt‐dependent Bcl2 up-regulation contribute to BDNF‐stimulated neural differentiation and to the survival of differentiated cells.
Journal ArticleDOI
Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways.
Chung Heon Ryu,Soon A Park,Seong Muk Kim,Jung Yeon Lim,Chang Hyun Jeong,Jin Ae Jun,Ji Hyeon Oh,Sun Hwa Park,Wonil Oh,Sin-Soo Jeun +9 more
TL;DR: Results demonstrate that Akt, ERK and p38 signal transduction pathways may be involved in SDF-1-mediated migration of hUCB-MSCs.
Journal ArticleDOI
Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy.
Seong Muk Kim,Ji Hyeon Oh,Soon A Park,Chung Heon Ryu,Jung Yeon Lim,Dal-Soo Kim,Jong Wook Chang,Wonil Oh,Sin-Soo Jeun +8 more
TL;DR: It is shown that tumor irradiation enhances the tumor tropism of human umbilical cord blood‐derived mesenchymal stem cells (UCB‐MSCs) and the therapeutic effect of TRAIL delivered by UCB‐ MSCs and that MSC‐based TRAIL gene delivery to irradiated tumors had greater therapeutic efficacy than a single treatment.
Journal ArticleDOI
CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas.
Soon A Park,Chung Heon Ryu,Seong Muk Kim,Jung Yeon Lim,Sang In Park,Chang Hyun Jeong,Jin Ae Jun,Ji Hyeon Oh,Sun Hwa Park,Wonil Oh,Sin-Soo Jeun +10 more
TL;DR: Results indicate that SDF-1α/CX CR4 could be involved in recruitment of hUCB-MSCs to glioma cells and that overexpression of CXCR4 may be a useful tool for stem cell-based gliomas therapy.