Jialiang Wang

TL;DR: It is concluded that acute administration of irisin lowers blood pressure of SHRs by amelioration of endothelial dysfunction of the mesenteric artery through the AMPK‐Akt‐eNOS‐NO signaling pathway.

TL;DR: It is indicated that the imbalance of renal RAS components was associated with increased oxidative stress in obese rats and antioxidant treatment with tempol reversed the imbalance and led to diuresis and natriuresis, which, at least in part, explains the blood pressure‐lowering effect of antioxidant supplementation in obesity‐related hypertension.

TL;DR: Findings indicate that curcumin down-regulates AT1R expression in A10 cells by affecting SP1/AT1R DNA binding, thus reducing At1R-mediated vasoconstriction and subsequently prevents the development of hypertension in an Ang II-induced hypertensive model.

TL;DR: The SRY gene in plasma EVs transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis; this mechanism provides a new approach to the understanding of inheritable CAD in men.

TL;DR: Pregnant LPS exposure, via an increase in oxidative stress, impairs renal D1R function and leads to hypertension in the offspring, and normalized after treatment with TEMPOL, an oxygen free radical scavenger.