Journal of the American Heart Association
About: Journal of the American Heart Association is an academic journal published by Wiley. The journal publishes majorly in the area(s): Medicine & Internal medicine. It has an ISSN identifier of 2047-9980. It is also open access. Over the lifetime, 8464 publications have been published receiving 207132 citations. The journal is also known as: Journal of the American Heart Association & JAHA.
TL;DR: Endurance, dynamic resistance, and isometric resistance training lower SBP and DBP, whereas combined training lowers only DBP.
Abstract: BackgroundWe conducted meta‐analyses examining the effects of endurance, dynamic resistance, combined endurance and resistance training, and isometric resistance training on resting blood pressure ...
TL;DR: There is increased risk of death following application of paclitaxel‐coated balloons and stents in the femoropopliteal artery of the lower limbs.
Abstract: Background Several randomized controlled trials (RCTs) have already shown that paclitaxel‐coated balloons and stents significantly reduce the rates of vessel restenosis and target lesion revascular...
University of Minnesota1, Erasmus University Rotterdam2, University of Iceland3, Boston University4, Ludwig Maximilian University of Munich5, Harvard University6, University of Washington7, Mayo Clinic8, Eppendorf (Germany)9, University of North Carolina at Chapel Hill10, Worcester Polytechnic Institute11, University of Massachusetts Medical School12, Wake Forest University13, National Institutes of Health14, University of Maryland Medical Center15
TL;DR: In this article, a simple 5-year predictive model including the variables age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes, and history of myocardial infarction and heart failure was used to predict atrial fibrillation.
Abstract: Background Tools for the prediction of atrial fibrillation (AF) may identify high-risk individuals more likely to benefit from preventive interventions and serve as a benchmark to test novel putative risk factors. Methods and Results Individual-level data from 3 large cohorts in the United States (Atherosclerosis Risk in Communities [ARIC] study, the Cardiovascular Health Study [CHS], and the Framingham Heart Study [FHS]), including 18 556 men and women aged 46 to 94 years (19% African Americans, 81% whites) were pooled to derive predictive models for AF using clinical variables. Validation of the derived models was performed in 7672 participants from the Age, Gene and Environment—Reykjavik study (AGES) and the Rotterdam Study (RS). The analysis included 1186 incident AF cases in the derivation cohorts and 585 in the validation cohorts. A simple 5-year predictive model including the variables age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes, and history of myocardial infarction and heart failure had good discrimination (C-statistic, 0.765; 95% CI, 0.748 to 0.781). Addition of variables from the electrocardiogram did not improve the overall model discrimination (C-statistic, 0.767; 95% CI, 0.750 to 0.783; categorical net reclassification improvement, −0.0032; 95% CI, −0.0178 to 0.0113). In the validation cohorts, discrimination was acceptable (AGES C-statistic, 0.664; 95% CI, 0.632 to 0.697 and RS C-statistic, 0.705; 95% CI, 0.664 to 0.747) and calibration was adequate. Conclusion A risk model including variables readily available in primary care settings adequately predicted AF in diverse populations from the United States and Europe.
TL;DR: Although significant heterogeneity is seen with single procedures, long‐term freedom from atrial arrhythmia can be achieved in some patients, but multiple procedures may be required.
Abstract: BackgroundIn the past decade, catheter ablation has become an established therapy for symptomatic atrial fibrillation (AF). Until very recently, few data have been available to guide the clinical c...
TL;DR: White matter hyperintensities (WMH) of presumed vascular origin, also referred to as leukoaraiosis, are a very common finding on brain magnetic resonance imaging or computed tomography in older subjects and in patients with stroke and dementia.
Abstract: White matter hyperintensities (WMH) of presumed vascular origin, also referred to as leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or computed tomography (CT) in older subjects and in patients with stroke and dementia. They are associated with cognitive