Two previously undescribed alkaloids, 4,4′-dihydroxy-3-methoxy-paucine-4′-O-β-D-glucopyranoside and (S)-2-(1,3-propanediol-2-yl)-isococlaurine, and three new lignans, (7R,8S)-9,9′-dihydroxy-3,4-dimethoxy-7,8-dihydrobenzofuran lignan, (7R,8S)-4,9,9′-trihydroxy-3,3′-dimethoxy-9′-acetoxy-7,8-dihydrobenzofuran lignan-4-O-β-D-glucopyranoside, and (7S,8R)-4,9,9′-trihydroxy-3,3′,5-trimethoxy-9′-acetoxy-7,8-dihydro-benzofuran lignan-4-O-β-D-glucopyranoside, together with eleven known compounds, were isolated from the flower buds of Magnolia biondii Pamp. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were deduced by analysis of optical rotation and electronic circular dichroic (ECD) spectra. All the isolated compounds were evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activity. As a result, it was found that (+)-isococlaurine exhibited the strongest AChE inhibitory effect. Molecular docking experiments were carried out to identify the probable binding mode of this compound in the binding sites of AChE and molecular dynamics simulations were performed to evaluate the stability over time of the main interactions observed during docking calculations.

Alkaloids and lignans with acetylcholinesterase inhibitory activity from the flower buds of Magnolia biondii Pamp

Iridoid glycosides and lignans from the fruits of Gardenia jasminoides Eills.

Molecular mechanism underlying anti-inflammatory activities of lirioresinol B dimethyl ether through suppression of NF-κB and MAPK signaling in in vitro and in vivo models.

Review of lignans from 2019 to 2021: Newly reported compounds, diverse activities, structure-activity relationships and clinical applications.

Five new phenylpropanoid glycosides from the flowers of Paulownia fortunei and their antioxidant activities

Four new monoterpenoid glycosides 1-4, named magnoliaterpenoid A-D, were isolated from a 50% aqueous acetone extract of flower buds of Magnolia biondii, along with one known compound, (1'R,3'S,5'R,8'S,2Z,4E)-dihydrophaseic acid 3-O-β-d-glucopyranoside (5). Their structures and relative configuration were identified by extensive spectroscopic analysis (IR, UV, MS, 1D and 2D NMR). The aglycones of these four new compounds possess seven-membered rings systems, which are very rare. A plausible biosynthetic route for the four new compounds was proposed via the biogenetic isoprene rule. Compounds 1, 2, 3, and 4 showed no antimicrobial activity at the concentration range of 1.95-250 µg/mL.

https://www.mdpi.com/1420-3049/21/6/728/pdf

Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii

Two new phenylpropanoids and a new dihydrostilbenoid from the flower buds of Magnolia biondii pamp and their acetylcholinesterase inhibitory activities.

Jian-Chao Wang

Papers

Alkaloids and lignans with acetylcholinesterase inhibitory activity from the flower buds of Magnolia biondii Pamp

Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii

Two new phenylpropanoids and a new dihydrostilbenoid from the flower buds of Magnolia biondii pamp and their acetylcholinesterase inhibitory activities.