J
Jian-Guo Cao
Researcher at University of South China
Publications - 6
Citations - 231
Jian-Guo Cao is an academic researcher from University of South China. The author has contributed to research in topics: Genistein & Chrysin. The author has an hindex of 5, co-authored 6 publications receiving 219 citations. Previous affiliations of Jian-Guo Cao include Donghua University & Hunan Normal University.
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Journal ArticleDOI
Synthesis and anticancer effect of chrysin derivatives
TL;DR: In this article, a series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocal carcininoma (HT-29) cells.
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Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids.
TL;DR: A series of B-ring trifluoromethylated flavonoids derivatives were prepared and tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and 5,7-dipropoxy-2-(4'-trifLUorometHylphenyl)-chromen-4-one 5c had the strongest activity against SGC- 197901 cell.
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Synthesis of genistein derivatives and determination of their protective effects against vascular endothelial cell damages caused by hydrogen peroxide.
TL;DR: Among these derivatives, 7-difluoromethyl-5,4'-dimethoxygenistein exhibited the strongest activity against hydrogen peroxide induced apoptosis of HUVE-12 cells.
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Synthesis and Anticancer Effect of Chrysin Derivatives.
TL;DR: In this article, a series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocal carcininoma (HT-29) cells.
Journal ArticleDOI
7-Difluoromethyl-5,4'-dimethoxygenistein, a novel genistein derivative, has therapeutic effects on atherosclerosis in a rabbit model.
Hong Zhao,Cheng Li,Jian-Guo Cao,Hong-Lin Xiang,Hua-Zhong Yang,Ji-Liang You,Cheng-Long Li,Xiao-Hua Fu +7 more
TL;DR: dFMGEN attenuated the development of atherosclerosis, reduced serum total cholesterol and low-density lipoprotein cholesterol concentrations, and decreased lipid peroxidation in the rabbit atheros sclerosis model, and increased smooth muscle cell and collagen content in atheroma of thoracic aortas.