J
Jian Lin
Researcher at Columbia University
Publications - 7
Citations - 1066
Jian Lin is an academic researcher from Columbia University. The author has contributed to research in topics: Cellular differentiation & Gene. The author has an hindex of 7, co-authored 7 publications receiving 1057 citations.
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Journal Article
Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.
TL;DR: It is demonstrated that p21 induction occurs during initiation of terminal differentiation in a p53-independent manner and may play a more global role in growth control and differentiation than originally envisioned.
Journal Article
The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.
Hongping Jiang,Jian Lin,Zao-Zhong Su,M. Herlyn,R. S. Kerbel,Bernard E. Weissman,Danny R. Welch,Paul B. Fisher +7 more
TL;DR: Two studies indicate that mda-6 (p21) may function as a negative regulator of melanoma growth, progression and metastasis.
Journal ArticleDOI
Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family
TL;DR: The approaches described in this paper, SEM combined with expression cloning, should prove of wide utility for developing immunological reagents specific for and identifying genes relevant to human cancer.
Journal Article
Growth Suppression and Toxicity Induced by Caffeic Acid Phenethyl Ester (CAPE) in Type 5 Adenovirus-transformed Rat Embryo Cells Correlate Directly with Transformation Progression
TL;DR: Evidence is presented indicating that sensitivity to CAPE is directly determined by the state of expression of the transformed progression phenotype, as opposed to simply theexpression of the Ad5 E1A and E1B transforming genes.
Journal Article
Human Prostatic Carcinoma Oncogene PTI-1 Is Expressed in Human Tumor Cell Lines and Prostate Carcinoma Patient Blood Samples
TL;DR: This study confirms the authenticity of the PTI-1 gene and documents its potential clinical utility as a sensitive and specific indicator of prostate cancer progression.