J
Jian-Mei Li
Researcher at University of Reading
Publications - 92
Citations - 7101
Jian-Mei Li is an academic researcher from University of Reading. The author has contributed to research in topics: NADPH oxidase & Oxidative stress. The author has an hindex of 42, co-authored 88 publications receiving 6733 citations. Previous affiliations of Jian-Mei Li include University of Surrey & St Thomas' Hospital.
Papers
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Journal ArticleDOI
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Jian-Mei Li,Ajay M. Shah +1 more
TL;DR: Current knowledge regarding the sources of endothelial ROS generation, their regulation, their involvement in redox signaling, and the relevance of enhanced ROS generation and redox signaled to the pathophysiology of cardiovascular disorders where endothelial activation and dysfunction are implicated are reviewed.
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Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure
TL;DR: expression and activity of phagocyte-type NADPH oxidase expressed in cardiomyocytes is a major source of ROS generation in pressure overload LV hypertrophy and may contribute to pathophysiological changes such as the activation of redox-sensitive kinases and progression to heart failure.
Journal ArticleDOI
Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells.
Jian-Mei Li,Ajay M. Shah +1 more
TL;DR: Results indicate that, in contrast to the neutrophil enzyme, a substantial proportion of the NADPH oxidase in unstimulated endothelial cells exists as a preassembled intracellular complex associated with the cytoskeleton.
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Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
Jonathan Byrne,David J. Grieve,Jennifer K. Bendall,Jian-Mei Li,Christopher Gove,J. David Lambeth,Alison C. Cave,Ajay M. Shah +7 more
TL;DR: Data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload, and the antioxidant, N-acetyl-cysteine, inhibited pressure-overload–induced LVH in both gp 91phox−/− and wild-type mice.
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Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.
Jian-Mei Li,Adrian M. Mullen,Sheng Yun,Frans B. Wientjes,Gabi Y. Brouns,Adrian J. Thrasher,Ajay M. Shah +6 more
TL;DR: Data show that endothelial cell p47phox is critical in the upregulation of NADPH oxidase activity by PMA and TNF&agr;.