Showing papers by "Jian Zheng published in 2013"
TL;DR: A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism.
182 citations
TL;DR: The Wittig difluoro-olefination anddifluorocyclopropanation could be selectively realized by using the same reagent, as the ylides obtained from different carbene sources showed different reactivity in Wittig reactions.
Abstract: The interconversion between difluoromethylene ylide and difluorocarbene is described. The difluoromethylene ylide precursor, Ph3P+CF2CO2-, could be turned into an efficient difluorocarbene reagent, whereas the classical difluorocarbene reagents, HCF2Cl an
125 citations
TL;DR: In this paper, a key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized.
Abstract: A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na–Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
4 citations