J
Jianming Lu
Researcher at Georgetown University
Publications - 21
Citations - 1386
Jianming Lu is an academic researcher from Georgetown University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 11 publications receiving 396 citations.
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Journal ArticleDOI
Structural impact on SARS-CoV-2 spike protein by D614G substitution.
Jun Zhang,Jun Zhang,Yongfei Cai,Yongfei Cai,Tianshu Xiao,Tianshu Xiao,Jianming Lu,Hanqin Peng,Sarah M. Sterling,Richard M. Walsh,Sophia Rits-Volloch,Haisun Zhu,Alec N. Woosley,Wei Yang,Piotr Sliz,Piotr Sliz,Bing Chen,Bing Chen +17 more
TL;DR: In this paper, the authors reported the structure of a full-length G614 S trimer, which adopts three distinct prefusion conformations that differ primarily by the position of one receptor-binding domain.
Journal ArticleDOI
Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.
Jun Zhang,Tianshu Xiao,Tianshu Xiao,Yongfei Cai,Yongfei Cai,Christy L. Lavine,Hanqin Peng,Haisun Zhu,Krishna Anand,Pei Tong,Avneesh Gautam,Avneesh Gautam,Megan L. Mayer,Richard M. Walsh,Sophia Rits-Volloch,Duane R. Wesemann,Duane R. Wesemann,Wei Yang,Michael S. Seaman,Jianming Lu,Bing Chen,Bing Chen +21 more
TL;DR: The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a dominant strain worldwide as discussed by the authors, and the structure, func...
Journal ArticleDOI
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.
Yongfei Cai,Yongfei Cai,Jun Zhang,Jun Zhang,Tianshu Xiao,Tianshu Xiao,Christy L. Lavine,Shaun Rawson,Hanqin Peng,Haisun Zhu,Krishna Anand,Pei Tong,Avneesh Gautam,Shen Lu,Sarah M. Sterling,Richard M. Walsh,Sophia Rits-Volloch,Jianming Lu,Duane R. Wesemann,Wei Yang,Michael S. Seaman,Bing Chen,Bing Chen +22 more
TL;DR: In this article, the full-length spike (S) trimers of the B.1.7 and B.351 variants of SARS-CoV-2 have been analyzed.
ComponentDOI
Structural basis of coreceptor recognition by HIV-1 envelope spike
Munan Shaik,Hanqin Peng,Jianming Lu,Sophia Rits-Volloch,Chen Xu,Maofu Liao,Bing Chen,Bing Chen +7 more
TL;DR: The cryo-electron microscopy structure of the gp120 component of the HIV-1 envelope glycoprotein, in complex with the primary receptor CD4 and coreceptor CCR5, provides insight into the cell-entry mechanism of HIV- 1.
Journal ArticleDOI
Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein
Jia Chen,James M. Kovacs,James M. Kovacs,Hanqin Peng,Sophia Rits-Volloch,Jianming Lu,Donghyun Park,Elise Zablowsky,Michael S. Seaman,Bing Chen,Bing Chen +10 more
TL;DR: Two conformationally homogeneous Envs derived from difficult-to-neutralize primary isolates are described, which yield a more accurate antigenic picture than hitherto possible of a genuinely untriggered and functional HIV-1 Env; they can guide effective vaccine development.