Tianshu Xiao

TL;DR: Two cryo–electron microscopy structures derived from a preparation of the full-length S protein, representing its prefusion and postfusion conformations, are reported, advancing the understanding of SARS-CoV-2 entry and may guide the development of vaccines and therapeutics.

TL;DR: Glycomics-informed glycoproteomics is utilized to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of human ACE2, which can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.

TL;DR: In this paper, the authors reported the structure of a full-length G614 S trimer, which adopts three distinct prefusion conformations that differ primarily by the position of one receptor-binding domain.

TL;DR: Two cryo-EM structures derived from a single preparation of the full-length S protein, representing the prefusion and postfusion conformations, advance the understanding of how SARS-CoV-2 enters a host cell and may guide development of vaccines and therapeutics.

TL;DR: The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a dominant strain worldwide as discussed by the authors, and the structure, func...