J
Jiannong Cen
Researcher at Soochow University (Suzhou)
Publications - 99
Citations - 805
Jiannong Cen is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 13, co-authored 99 publications receiving 678 citations. Previous affiliations of Jiannong Cen include Chinese Ministry of Science and Technology.
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Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.
TL;DR: The findings suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS in acute leukemia.
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The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells
TL;DR: This study indicated that increasing TIMP-2 in AML patients with EMI may potentially cause adverse effects, particularly in patients containing high levels of MMP-2 and MT1-MMP.
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Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia.
Tianhui Liu,Lijun Wen,Hongjian Yuan,Yi Wang,Li Yao,Yang Xu,Jiannong Cen,Changgeng Ruan,Depei Wu,Suning Chen +9 more
TL;DR: Retinoic acid receptor γ (RARG) is a member of the nuclear receptor superfamily and shares high homology (90%) with retinoic Acid receptor α (RARA) and retinoIC acid receptor β (RARB).[1]
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Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome
Jiang Lin,Dong-ming Yao,Jun Qian,Ya-li Wang,Lan-xiu Han,Yun-Wei Jiang,Xia Fei,Jiannong Cen,Zi-Xing Chen +8 more
TL;DR: The results suggested that aberrant methylation of the FHIT gene might be one of molecular events involved in the disease progression of MDS and be an adverse prognostic factor in MDS.
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Expanded donor natural killer cell and IL‐2, IL‐15 treatment efficacy in allogeneic hematopoietic stem cell transplantation
Guanghua Chen,Depei Wu,Yi Wang,Jiannong Cen,Yufeng Feng,Aining Sun,Xiaowen Tang,Huirong Chang,Zi-Ling Zhu +8 more
TL;DR: Investigation of the administration of expanded donor NK cell infusion and interleukin‐2 (IL‐2) and IL‐15 mixture treatment in a murine allo‐HSCT model found it could promote lymphoid immune reconstitution, mitigate GVHD, and reduce leukemia relapse in allo-HSCT recipients.