J
Jianping Chen
Researcher at University of Texas Medical Branch
Publications - 14
Citations - 155
Jianping Chen is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 5 publications receiving 83 citations.
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Journal ArticleDOI
Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.
TL;DR: This Perspective provides an update on allosterically targeted class A GPCRs and their disease indications and the medicinal chemistry approaches toward novel allosteric modulators and highlights emerging trends and opportunities in the field.
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Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.
Eric A. Wold,Erik J. Garcia,Christopher Wild,Joanna Miszkiel,Claudia A. Soto,Jianping Chen,Konrad Pazdrak,Robert G. Fox,Noelle C. Anastasio,Kathryn A. Cunningham,Jia Zhou +10 more
TL;DR: Compound 12 (CTW0415) was discovered as a 5-HT2CR PAM with improved pharmacokinetics and reduced off-target interactions relative to the previous series of molecules, and the in vivo efficacy of compound 12 to potentiate the effects of a selective 5- HT2CR agonist was established in a drug discrimination assay.
Journal ArticleDOI
Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.
Yi Li,Jianping Chen,Andrew A Bolinger,Haiying Chen,Zhiqing Liu,Yingzi Cong,Allan R. Brasier,Irina V. Pinchuk,Bing Tian,Jia Zhou +9 more
TL;DR: In this paper, the authors summarized the recent advances in drug discovery of new small molecules in preclinical or clinical development for treating IBD that target biologically relevant pathways in mucosal inflammation.
Journal ArticleDOI
Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers
Yi Li,Zhiqing Liu,Galina V. Aglyamova,Jianping Chen,Haiying Chen,Mukund Bhandari,Mark A. White,Gabrielle Rudenko,Jia Zhou +8 more
TL;DR: The identification of a novel phenanthridine analogue ZL0220 as an active and promising ΔfosB chemical probe with micromolar inhibitory activities against ΔFosB homodimers and ΔFOSB/JunD heterodIMers is described.