Y
Yingzi Cong
Researcher at University of Texas Medical Branch
Publications - 179
Citations - 12053
Yingzi Cong is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 51, co-authored 152 publications receiving 9550 citations. Previous affiliations of Yingzi Cong include Shandong University & University of Alabama at Birmingham.
Papers
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Journal ArticleDOI
Bacterial flagellin is a dominant antigen in Crohn disease
Michael J. Lodes,Yingzi Cong,Charles O. Elson,Raodoh Mohamath,Carol J. Landers,Stephan R. Targan,Madeline Fort,Robert M. Hershberg,Robert M. Hershberg +8 more
TL;DR: Serological expression cloning was used to identify commensal bacterial proteins that could contribute to the pathogenesis of IBD and identify flagellins as a class of immunodominant antigens that stimulate pathogenic intestinal immune reactions in genetically diverse hosts.
Journal ArticleDOI
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.
TL;DR: Recent progresses of SCFA in regulation of intestinal homeostasis as well as in pathogenesis of IBD are summarized.
Journal ArticleDOI
Experimental Models of Inflammatory Bowel Disease Reveal Innate, Adaptive, and Regulatory Mechanisms of Host Dialogue With the Microbiota
Charles O. Elson,Yingzi Cong,Vance J. McCracken,Reed A. Dimmitt,Robin G. Lorenz,Casey T. Weaver +5 more
TL;DR: The thesis is advanced that ‘multiple hits’ or defects in these interacting components is required for IBD to occur in both mouse and human.
Journal ArticleDOI
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.
Stephan R. Targan,Carol J. Landers,Huiying Yang,Michael J. Lodes,Michael J. Lodes,Yingzi Cong,Yingzi Cong,Konstantinos A. Papadakis,Eric A. Vasiliauskas,Charles O. Elson,Charles O. Elson,Robert M. Hershberg,Robert M. Hershberg +12 more
TL;DR: Serum responses to CBir1 independently identify a unique subset of patients with complicated CD patients, and this bacterial antigen was identified in a murine model and has a similar pattern of aberrant reactivity in a subset of CD patients.
Journal ArticleDOI
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.
Charles O. Elson,Yingzi Cong,Casey T. Weaver,Trenton R. Schoeb,Terrill K. McClanahan,Robert B. Fick,Robert A. Kastelein +6 more
TL;DR: Bacterial-reactive CD4(+) Th17 cells are potent effector cells in chronic colitis and IL-23 is an attractive therapeutic target for inflammatory bowel disease.