The rationale for the present study was to develop porous CaP/silk composite scaffolds with a CaP-phase
distribution and pore architecture better suited to facilitate osteogenic properties of human bone
mesenchymal stromal cells (BMSCs) and in vivo bone formation abilities This was achieved by first
preparing CaP/silk hybrid powders which were then incorporated into silk to obtain uniform CaP/silk
composite scaffolds, by means of a freeze-drying method The composition, microstructure and
mechanical properties of the CaP/silk composite scaffolds were ascertained by X-ray diffraction (XRD),
Fourier transform infrared spectra (FTIR), scanning electron microscope (SEM) and a universal mechanical
testing machine BMSCs were cultured in these scaffolds and cell proliferation analyzed by confocal
microscopy and MTS assay Alkaline phosphatase (ALP) activity and osteogenic gene expression were
assayed to determine if osteogenic differentiation had taken place A calvarial defect model in SCID mice
was used to determine the in vivo bone forming ability of the hybrid CaP/silk scaffolds Our results showed
that incorporating the hybrid CaP/silk powders into silk scaffolds improved both pore structure architecture
and distribution of CaP powders in the composite scaffolds By incorporating the CaP phase into
silk scaffolds in vitro osteogenic differentiation of BMSCs was enhanced and there was increased in vivo
cancellous bone formation Here we report a method with which to prepare Ca/P composite scaffolds with
a pore structure and Ca/P distribution better suited to facilitate BMSC differentiation and bone formation

The osteogenic properties of CaP/silk composite scaffolds

Recent advances in polymeric transdermal drug delivery systems.

Recent advances in polymeric transdermal drug delivery systems

Alginate is a natural polysaccharide that is easily chemically modified or compounded with other components for various types of functionalities. The alginate derivatives are appealing not only because they are biocompatible so that they can be used in biomedicine or tissue engineering but also because of the prospering bioelectronics that require various biomaterials to interface between human tissues and electronics or to serve as electronic components themselves. The study of alginate-based materials, especially hydrogels, have repeatedly found new frontiers over recent years. In this Review, we document the basic properties of alginate, their chemical modification strategies, and the recent development of alginate-based functional composite materials. The newly thrived functions such as ionically conductive hydrogel or 3D or 4D cell culturing matrix are emphasized among other appealing potential applications. We expect that the documentation of relevant information will stimulate scientific efforts to further develop biocompatible electronics or smart materials and to help the research domain better address the medicine, energy, and environmental challenges faced by human societies.

Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses.

Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed

https://www.mdpi.com/2073-4352/11/4/353/pdf

Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair.

In recent years, hydrogel-based research in biomedical engineering has attracted more attention. Cellulose-based hydrogels have become a research hotspot in the field of functional materials because of their outstanding characteristics such as excellent flexibility, stimulus-response, biocompatibility, and degradability. In addition, cellulose-based hydrogel materials exhibit excellent mechanical properties and designable functions through different preparation methods and structure designs, demonstrating huge development potential. In this review, we have systematically summarized sources and types of cellulose and the formation mechanism of the hydrogel. We have reviewed and discussed the recent progress in the development of cellulose-based hydrogels and introduced their applications such as ionic conduction, thermal insulation, and drug delivery. Also, we analyzed and highlighted the trends and opportunities for the further development of cellulose-based hydrogels as emerging materials in the future.

/pdf/advances-in-cellulose-based-hydrogels-for-biomedical-3mk4lsde.pdf

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis

Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis

The invention relates to a preparation method of green fluorescent xonotlite nanocrystal, which comprises the following steps: adding calcium oleate, magnesium oleate and a phosphate solution into anoleic acid and ethanol reaction system, uniformly mixing, fully reacting at the temperature of 100-180 DEG C, adding terbium nitrate into the mixture, and continuously reacting, and obtaining the terbium-doped xonotlite nanocrystal with bright green fluorescence characteristic. The nanocrystal with the green fluorescence characteristic can be applied to fluorescence labeling of living cells, can also be used as an inorganic raw material for preparing a biomedical stent material, and has a wide application prospect.

Jiaxin Yao

Papers

A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair.

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis

Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semi-inter penetrating polymer network (Semi-IPN) for solar dermatitis

Preparation method of green fluorescent xonotlite nanocrystal