Jie Fang

TL;DR: The results indicated that Cur-NPs showed enhanced therapeutic effects than that of curcumin in improving neurological function, reducing brain water content, and Evans blue dye extravasation after SAH, and revealed that the strategy of using Cur- NPs could be a promising way in improved neurological function in EBI after experimental rat SAH.

TL;DR: The results indicate that intraperitoneal administration of Carnosine significantly attenuates brain edema, blood–brain barrier disruption, oxidative stress, microglia activation and neuronal apoptosis of perihematoma at 72 h following ICH in rats models, and suggest that Carno may provide neuroprotective effect after experimental ICH.

TL;DR: It is found that selective mGluR5 orthosteric agonist CHPG or positive allosteric modulator VU0360172 administration significantly improves neurological function and attenuates brain edema in EBI after SAH.

TL;DR: It is found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood–brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models, indicating that administration of Carnosine may provide neuroprotection in EBI followingSAH in rats.

TL;DR: The results suggested that high glucose showed significant cytotoxicity through launching mitochondria-mediated apoptosis in PC12 cells, accompanied by poly (ADP-ribose) polymerase (PARP) cleavage, caspase activation, and mitochondrial dysfunction, but 3,3′-diselenodipropionic acid (DSePA), a derivative of selenocystine, demonstrated its protective effect against high glucose-induced neurotoxicity.