J
Jie Wang
Researcher at University of Tennessee Health Science Center
Publications - 15
Citations - 810
Jie Wang is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Interferon & Virus. The author has an hindex of 6, co-authored 6 publications receiving 688 citations.
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Journal ArticleDOI
Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases
Mark A. Clementz,Zhongbin Chen,Bridget S. Banach,Yanhua Wang,Li Sun,Kiira Ratia,Yahira M. Báez-Santos,Jie Wang,Jun Takayama,Arun K. Ghosh,Kui Li,Andrew D. Mesecar,Susan C. Baker +12 more
TL;DR: The results indicated that a component of coronavirus PLP-mediated interferon antagonism was independent of protease and DUB activity, and suggest that these independent activities may provide multiple targets for antiviral therapies.
Journal ArticleDOI
Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells
TL;DR: It is shown that primary human hepatocytes express TLR3 and robustly upregulate ISGs upon poly(I·C) stimulation and thatTLR3 senses hepatitis C virus (HCV) infection when expressed in permissive hepatoma cells, acting independently of retinoic acid-inducible gene I and inducing IRF-3 activation and the synthesis of ISGs that restrict virus replication.
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TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection
TL;DR: The data demonstrate that TRIM56 is a novel antiviral host factor that restricts pestivirus infection and is not attributed to a general augmentation of the interferon antiviral response.
Journal ArticleDOI
Antiviral activities of ISG20 in positive-strand RNA virus infections.
Zhi Zhou,Nan Wang,Sara E. Woodson,Qingming Dong,Jie Wang,Yuqiong Liang,Rene Rijnbrand,Rene Rijnbrand,Lai Wei,Joan E. Nichols,Ju-Tao Guo,Michael R. Holbrook,Michael R. Holbrook,Stanley M. Lemon,Stanley M. Lemon,Kui Li +15 more
TL;DR: Overexpression of ISG20 did not inhibit propagation of severe acute respiratory syndrome coronavirus, a highly-pathogenic human coronav virus in Huh7.5 cells, and the closely related cellular exonucleases,ISG20L1 and ISG 20L2, did not inhibits HCV replication.
Journal ArticleDOI
Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of TRIM56 against Flaviviruses and Coronavirus
TL;DR: Tripartite motif protein 56 (TRIM56) is a versatile antiviral host factor that confers resistance to YFV, DENV2, and HCoV-OC43 through overlapping and distinct molecular determinants.