J
Jih-Hwa Guh
Researcher at National Taiwan University
Publications - 176
Citations - 4933
Jih-Hwa Guh is an academic researcher from National Taiwan University. The author has contributed to research in topics: Apoptosis & Cell cycle. The author has an hindex of 40, co-authored 173 publications receiving 4501 citations. Previous affiliations of Jih-Hwa Guh include Sun Yat-sen University & Ohio State University.
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Journal ArticleDOI
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.
Ting Chun Yeh,Po Cheng Chiang,Tsai-Kun Li,Jui-Ling Hsu,Chun-Jung Lin,Shih-Wei Wang,Chieh Yu Peng,Jih-Hwa Guh +7 more
TL;DR: It is suggested that genistein induces the anticancer effect through a mechanism initiated by ER stress and facilitated by mitochondrial insult in Hep3B cells.
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Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.
Po-Cheng Chiang,Ssu-Chia Lin,Shiow-Lin Pan,Ching-Hua Kuo,I-Lin Tsai,Mao-Tien Kuo,Wu-Che Wen,Peini Chen,Jih-Hwa Guh,Jih-Hwa Guh +9 more
TL;DR: The data suggest that antroquinonol displays anticancer activity against HCCs through AMPK activation and inhibition of mTOR translational pathway, leading to G1 arrest of the cell-cycle and subsequent cell apoptosis.
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Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
Cho Hwa Liao,Shiow Lin Pan,Jih-Hwa Guh,Ya Ling Chang,Hui Chen Pai,Chun Hung Lin,Che-Ming Teng +6 more
TL;DR: The antitumor activity of evodiamine against the human multiple-drug resistant tumor xenograft was found to be superior to that of paclitaxel, and represents a highly promising chemotherapeutic agent in the treatment of human multiple -drug resistant cancer cells.
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Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells
TL;DR: GO-13 is the most effective anticancer compound in the screening tests and showed equivalent anti-angiogenic activity in the nude mice angiogenesis model and is positively correlated with the increase in caspase-3 activity.
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Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells
TL;DR: It is suggested that ouabain induces two modes of cytotoxic effect in human hormone-independent prostate cancer PC-3 cells using mitochondrial MTT reduction assays and an antisense, but not nonsense, oligomer against Par-4 expression significantly inhibited the cytotoxicity induced by low concentrations of ouABain.