Jihee Kim

TL;DR: Cardioprotective effects of EPO were seen without an increase in hematocrit (eliminating oxygen delivery as an etiologic factor in myocyte survival and function), demonstrating that EPO can directly protect the ischemic and infarcted heart.

TL;DR: It is demonstrated that ligand binding to the decoy receptor CXCR7 does not result in activation of signaling pathways typical of G proteins but does activate MAP kinases through β-arrestin in transiently transfected cells, which suggests that other receptors that are currently thought to be orphans or decoys may also signal through such nonclassical pathways.

TL;DR: Findings indicate distinct functional capabilities of beta-arrestins bound to receptors phosphorylated by different classes of GRKs, which are related to receptor recruitment, recruitment, and receptor endocytosis.

TL;DR: The results suggest that beta-arrestin recruited in response to receptor phosphorylation by different GRKs has distinct functional potentials.

TL;DR: It is demonstrated that β-arrestins mediate the activity-dependent interaction of Smo and the kinesin motor protein Kif3A and suggested roles for β-Arrestins in mediating the intracellular transport of a 7TMR to its obligate subcellular location for signaling.