A
Akio Matsumoto
Researcher at Chiba University
Publications - 51
Citations - 5564
Akio Matsumoto is an academic researcher from Chiba University. The author has contributed to research in topics: Signal transduction & Fucosylation. The author has an hindex of 24, co-authored 50 publications receiving 5246 citations. Previous affiliations of Akio Matsumoto include Hokkaido University & Osaka University.
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Journal ArticleDOI
Protein S-nitrosylation: purview and parameters.
Douglas T. Hess,Akio Matsumoto,Sung Oog Kim,Harvey E. Marshall,Jonathan S. Stamler,Jonathan S. Stamler +5 more
TL;DR: S-nitrosylation conveys a large part of the ubiquitous influence of nitric oxide on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
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A novel protective effect of erythropoietin in the infarcted heart
Cyrus J. Parsa,Akio Matsumoto,Jihee Kim,Ryan U. Riel,Laura S. Pascal,G. Brant Walton,Richard B. Thompson,Jason A. Petrofski,Brian H. Annex,Jonathan S. Stamler,Walter J. Koch,Walter J. Koch +11 more
TL;DR: Cardioprotective effects of EPO were seen without an increase in hematocrit (eliminating oxygen delivery as an etiologic factor in myocyte survival and function), demonstrating that EPO can directly protect the ischemic and infarcted heart.
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Functional roles of N-glycans in cell signaling and cell adhesion in cancer.
Yanyang Zhao,Motoko Takahashi,Jianguo Gu,Eiji Miyoshi,Akio Matsumoto,Shinobu Kitazume,Naoyuki Taniguchi +6 more
TL;DR: It is suggested that the modulation of N‐glycans of those receptors alters their important functions such as cell signaling and cell adhesion which are implicated in cancer invasion and metastasis.
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Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
Erin J. Whalen,Matthew W. Foster,Akio Matsumoto,Kentaro Ozawa,Jonathan D. Violin,Loretta G. Que,Christopher D. Nelson,Moran Benhar,Janelle R. Keys,Howard A. Rockman,Walter J. Koch,Yehia Daaka,Robert J. Lefkowitz,Robert J. Lefkowitz,Jonathan S. Stamler +14 more
TL;DR: It is shown in mice that SNOs increase beta- AR expression and prevent agonist-stimulated receptor downregulation; and in cells, SNOs decrease GRK2-mediated beta-AR phosphorylation and subsequent recruitment of beta-arrestin to the receptor, resulting in the attenuation of receptor desensitization and internalization.
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S-nitrosylation: spectrum and specificity.
TL;DR: Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation and specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in space.