J
Jin Guo
Researcher at University of California, Los Angeles
Publications - 31
Citations - 879
Jin Guo is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Thyroid peroxidase & Epitope. The author has an hindex of 20, co-authored 31 publications receiving 864 citations. Previous affiliations of Jin Guo include University of California, San Francisco & United States Department of Veterans Affairs.
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Journal ArticleDOI
Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies.
TL;DR: A human TPO-specific Fab converted to IgG1, but not IgG-4, can mediate cytotoxic effects on human thyroid cells in vitro and support the clinical relevance of TPO autoantibody subclass distribution.
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A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies.
Gregorio D. Chazenbalk,Yan Wang,Jin Guo,J S Hutchison,D. Segal,Juan Carlos Jaume,Sandra M. McLachlan,Basil Rapoport +7 more
TL;DR: Studies involving a TSHR ectodomain variant indicate the exquisite conformational requirements of TSHr autoantibodies, as even under "native" conditions, only a minority of molecules in highly potent T SHR-289 preparations neutralize patients' autoantIBodies.
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Naked TSH Receptor DNA Vaccination: A TH1 T Cell Response in Which Interferon-γ Production, Rather than Antibody, Dominates the Immune Response in Mice
Pavel N. Pichurin,Xin-Min Yan,Loredana Farilla,Jin Guo,Gregorio D. Chazenbalk,Basil Rapoport,Sandra M. McLachlan +6 more
TL;DR: Two approaches have been developed to induce TSH receptor antibodies in mice with properties resembling those in Graves’ disease, the Shimojo model of injecting live fibroblasts coexpressing the TSH receptors and the major histocompatibility complex antigen class II, and T SH receptor-DNA vaccination.
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Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".
Juan Carlos Jaume,Juan Carlos Jaume,Jin Guo,David L. Pauls,M. Zakarija,J. Maxwell McKenzie,Janice A. Egeland,C. Lynne Burek,Noel R. Rose,William H. Hoffman,Basil Rapoport,Sandra M. McLachlan,Sandra M. McLachlan +12 more
TL;DR: It is suggested that autoantibody recognition of the T PO immunodominant region and the TPO B domain is genetically transmitted and may open the way to the identification by candidate analysis or positional cloning of at least one gene responsible for the development of Hashimoto's thyroiditis.
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Role of MHC class I expression and CD8+ T cells in the evolution of iodine-induced thyroiditis in NOD-H2h4 and NOD mice
TL;DR: Histological analyses of the thyroids show that following 1 week of iodine administration MHC class I expression is elevated on thyroid follicular cells and CD4+ and CD8+ T cells have begun to infiltrate the gland, suggesting that cytokine production by infiltrating lymphocytes was responsible for the increased MHC expression.