J
Jin Hyen Baek
Researcher at Johns Hopkins University
Publications - 24
Citations - 2569
Jin Hyen Baek is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Apoptosis & DNA methylation. The author has an hindex of 16, co-authored 21 publications receiving 2424 citations. Previous affiliations of Jin Hyen Baek include Johns Hopkins University School of Medicine & Pusan National University.
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Journal ArticleDOI
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes.
Myoung Sook Kim,Ho Jeong Kwon,You Mie Lee,Jin Hyen Baek,Jae Eun Jang,Sae Won Lee,Eun Joung Moon,Hae Sun Kim,Seok Ki Lee,Hae Young Chung,Chul Woo Kim,Kyu Won Kim +11 more
TL;DR: It is indicated that hypoxia enhances HDAC function and that HDAC is closely involved in angiogenesis through suppression of Hypoxia-responsive tumor suppressor genes.
Journal Article
Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA
TL;DR: It is suggested that loosening-up the chromatin structure by histone acetylation can increase the efficiency of several anticancer drugs targeting DNA, which may be advantageous for treating tumors intrinsically resistant to these drugs.
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Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells.
Nathaniel S. Hwang,Myoung Sook Kim,Somponnat Sampattavanich,Jin Hyen Baek,Zijun Zhang,Jennifer H. Elisseeff +5 more
TL;DR: It is hypothesized that a supportive three‐dimensional environment provides ES cell‐derived cells an environment that more closely mimics chondrogenesis in vivo, and suggests that EB‐PEG hydrogel culture, with an appropriate growth factor, may provide a suitable environment forChondrogenic differentiation of intact ES cell-derived EBs.
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Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
TL;DR: It is proposed that hypoxia enhances survival of nutrient-depleted tumor cells by reducing susceptibility to apoptosis, which consequently leads to tumor malignancy.
Journal ArticleDOI
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma
Myoung Sook Kim,Xiaofei Chang,Keishi Yamashita,Jatin K. Nagpal,Jin Hyen Baek,Guojun Wu,Barry Trink,Edward A. Ratovitski,Masaki Mori,David Sidransky +9 more
TL;DR: The data implicate DFNA5 as a novel tumor suppressor gene in CRC and a valuable molecular marker for human cancer.