Jin-Wen Song

TL;DR: In this article, a combination of blocking CD39/adenosine and PD-1 signaling showed a synergic effect in restoring CD8+ T-cell function, as evidenced by enhanced abilities to secrete functional cytokines and to kill autologous reservoir cells.

TL;DR: The skewed CD39 and CD73 expression on B-cells was associated with a high viral burden, liver inflammation, and antiviral efficacy in CHB patients, and the skewedCD39/CD73/adenosine pathway contributed to B-cell hyperactivation.

TL;DR: In this paper, the dynamics of viral reservoir decay and naive CD4 T-cell recovery between immunological nonresponders (INR) and complete responders (CR) during long-term antiretroviral treatment (ART) are not fully known.

TL;DR: High CD8 counts are beneficial for persistent viral decay and CD4 recovery in immune restored patients during long-term ART, and reduced HIV DNA levels and increased CD4 counts between years 3 and 5 of ART were positively correlated withCD8 counts and function.

TL;DR: Wang et al. as discussed by the authors performed single-cell RNA sequencing (scRNA-seq) on the peripheral T cells of 14 individuals with chronic human immunodeficiency virus 1 (HIV-1) infection, including nine treatment-naive (TP) and eight antiretroviral therapy (ART) participants, and compared the results with four healthy donors (HD).