Showing papers by "Jin Zhong published in 2013"
TL;DR: A novel NS3/4A-independent mechanism HCV utilizes to evade host innate immune responses in which viral NS4B protein targets STING/MITA to suppress the interferon signaling is reported.
155 citations
TL;DR: The data suggest that activation of the NLRP3 inflammasome by M.hy may be associated with its promotion of gastric cancer metastasis, and anti-M.hy therapy or limitingNLRP3 signaling could be effective approach for control of Gastric cancer progress.
Abstract: Background
Mycoplasma hyorhinis (M.hyorhinis, M.hy) is associated with development of gastric and prostate cancers. The NLRP3 inflammasome, a protein complex controlling maturation of important pro-inflammatory cytokines interleukin (IL)-1β and IL-18, is also involved in tumorigenesis and metastasis of various cancers.
66 citations
TL;DR: SET7-mediated monomethylation of IFITM3 at Lys-88 negatively affected its antiviral activity toward vesicular stomatitis virus (VSV) and influenza A virus (IAV) infection.
42 citations
TL;DR: It is demonstrated that POM-12 had no effect on the vesicular stomatitis virus infection while had weak inhibitory activity against the influenza virus infection.
33 citations
TL;DR: Developing 1b/JFH-1 inter-genotypic recombinants containing the structural genes (Core, E1, E2, p7 and the 1stTMD of NS2 directly from GT1b clinical isolates will be important for studies of isolate-specific neutralization and useful in evaluating antiviral therapies.
19 citations
TL;DR: The findings suggest that DDB1 is a cellular substrate of NS3/4A required for HCV replication and provide new insight into the interaction between HCV and host cells.
17 citations
Journal Article•
TL;DR: A new way to construct cell surface display system of lactic acid bacteria by using ice nucleation protein is suggested.
Abstract: Objective The gene of ice nucleation protein (INP), an outer membrane of Pseudomonas syringae was tested to display foreign proteins on the surface of Lactococcus lactis. Methods Plasmids pHZ101 and pHZ102 were constructed using gfp (Green Fluorescence Protein) as the reporter gene and N-terminal and NC-terminal of inp as the anchoring units. Plasmids pHZ101 and pHZ102 were subsequently transformed into Escherichia coli JM109 and Lactococcus lactis MG1363. Results Fluorescence microscope shows that green fluorescence was observed in both recombinant E. coli and L. lactis strains. Western blot indicated that GFP was expressed in both recombinant E. coli and L. lactis strains. INPN-GFP was mostly trapped in cytoplastic fraction while INPNC-GFP was mainly targeted on the cell membrane of L. lactis. Conclusion The results suggest a new way to construct cell surface display system of lactic acid bacteria by using ice nucleation protein.
2 citations