Bing Sun

TL;DR: This work finds that curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity and offers a mechanistic basis for the therapeutic potential ofCurcumin in septic shock and other NLRP2 inflammaome-driven diseases.

TL;DR: It is indicated that TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting degradation of TAB2 and TAB3 by a 'feedback' mechanism.

TL;DR: The structures of this HCV viroporin as well as its drug-binding site are determined using the latest nuclear magnetic resonance (NMR) technologies to provide a molecular explanation for p7-mediated cation conductance and its inhibition by adamantane derivatives.

TL;DR: It is suggested that viral ion channels, in general, may be a good target for the development of antiviral agents, and that kaempferol glycosides are good candidates for 3a channel proteins of coronaviruses.

TL;DR: It is suggested that anti-S and anti-N antibodies are diagnostic markers and in particular that S3 is immunogenic and therefore is a good candidate as a subunit vaccine antigen; and that, from a virus structure viewpoint, the presence in some human sera of antibodies reacting with two recombinant polypeptides, 3a and 9b, supports the hypothesis that they are synthesized during the virus cycle.