J
Jindong Xie
Publications - 16
Citations - 637
Jindong Xie is an academic researcher. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 1, co-authored 1 publications receiving 402 citations.
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Journal ArticleDOI
CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Gang Luo,Mark R. Cunningham,Sean Kim,Tim Burn,Jianrong Lin,Michael Sinz,Geraldine A. Hamilton,Christopher Rizzo,Summer Jolley,Darryl Gilbert,April Downey,Daniel R. Mudra,Richard A. Graham,Kathy Carroll,Jindong Xie,Ajay Madan,Andrew Parkinson,Dave Christ,Bernard H. Selling,Edward L. LeCluyse,Liang-Shang Gan +20 more
TL;DR: It is concluded that the PXR reporter gene assay is a reliable and complementary method to assess the CYP3A4 induction potential of drugs and other xenobiotics.
Journal ArticleDOI
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Yu-chao Zou,Jindong Xie,Shaoquan Zheng,Wen-qing Liu,Yu-Chien Tang,Wenwen Tian,Xinpei Deng,Linyu Wu,Yue Zhang,Chau Wei Wong,Duxun Tan,Qing Jian Liu,Xiaolin Xie +12 more
TL;DR: Wang et al. as discussed by the authors established a novel cell death index (CDI) model by comprehensively analyzing diverse cell death patterns, which can accurately predict clinical prognosis and drug sensitivity of TNBC after surgery.
Journal ArticleDOI
The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer
Yu-chao Zou,Feng Ye,Yanan Kong,Xiaoqian Hu,Xinpei Deng,Jindong Xie,Cailu Song,Xueqi Ou,Song Wu,Linyu Wu,Yi Xie,Wenwen Tian,Yu-Chien Tang,Chau Wei Wong,Zhe S Chen,Xinhua Xie,Hailin Tang +16 more
TL;DR: In this article , a high-resolution map of the entire tumor ecosystem based on 44 473 cells from breast cancer liver and brain metastases is depicted using single-cell RNA sequencing.
Journal ArticleDOI
Prognosis and Dissection of Immunosuppressive Microenvironment in Breast Cancer Based on Fatty Acid Metabolism-Related Signature
Yu-Chien Tang,Wenwen Tian,Jindong Xie,Yu-chao Zou,Zehao Wang,Ning Liu,Yan Zeng,Linyu Wu,Yue Zhang,Song Wu,Xiaolin Xie,Lu Yang +11 more
TL;DR: In this paper , a prognostic signature based on 6 overall survival (OS)-related FMGs was generated using Lasso Cox hazards regression analysis in TCGA dataset and was validated in two external cohorts.
Journal ArticleDOI
Establishment of a Cell Necroptosis Index to Predict Prognosis and Drug Sensitivity for Patients With Triple-Negative Breast Cancer
Jindong Xie,Wenwen Tian,Yu-Chien Tang,Yu-chao Zou,Shaoquan Zheng,Linyu Wu,Yan Zeng,Song Wu,Xinhua Xie,Xiaolin Xie +9 more
TL;DR: The novel prognostic marker CNI could not only precisely predict the survival probability of patients with TNBC but also demonstrate a potential role in antitumor immunity and drug sensitivity.