Y
Yue Zhang
Researcher at Novartis
Publications - 29
Citations - 4231
Yue Zhang is an academic researcher from Novartis. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 12 publications receiving 3506 citations. Previous affiliations of Yue Zhang include University of Wisconsin-Madison & AstraZeneca.
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Journal ArticleDOI
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih Min A Huang,Yuji Mishina,Shanming Liu,Atwood K. Cheung,Frank Stegmeier,Gregory A. Michaud,Olga Charlat,Elizabeth Wiellette,Yue Zhang,Stephanie Wiessner,Marc Hild,Xiaoying Shi,Christine D. Wilson,Craig Mickanin,Vic E. Myer,Aleem Fazal,Ronald Tomlinson,Fabrizio C. Serluca,Wenlin Shao,Hong Cheng,Michael Shultz,Christina Rau,Markus Schirle,Judith Schlegl,Sonja Ghidelli,Stephen Fawell,Chris Lu,Daniel Curtis,Marc W. Kirschner,Christoph Lengauer,Peter Finan,John A. Tallarico,Tewis Bouwmeester,Jeffery A. Porter,Andreas Bauer,Feng Cong +35 more
TL;DR: This study uses a chemical genetic screen to identify a small molecule, XAV939, which selectively inhibits β-catenin-mediated transcription and reveals new mechanistic insights into the regulation of axin protein homeostasis, which presents new avenues for targeted Wnt pathway therapies.
Journal ArticleDOI
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
Huaixiang Hao,Yang Xie,Yue Zhang,Yue Zhang,Olga Charlat,Emma Oster,Monika Avello,Hong Lei,Craig Mickanin,Dong Liu,Heinz Ruffner,Xiaohong Mao,Qicheng Ma,Raffaella Zamponi,Tewis Bouwmeester,Peter Finan,Marc W. Kirschner,Jeffery A. Porter,Fabrizio C. Serluca,Feng Cong +19 more
TL;DR: It is shown that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling, and R-spondin mimics ZNRF3 inhibition by increasing the membrane level of WNT receptors.
Journal ArticleDOI
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Yue Zhang,Shanming Liu,Craig Mickanin,Yan Feng,Olga Charlat,Gregory A. Michaud,Markus Schirle,Xiaoying Shi,Marc Hild,Andreas Bauer,Vic E. Myer,Peter Finan,Jeffery A. Porter,Shih-Min A. Huang,Feng Cong +14 more
TL;DR: Identification of RNF146, a RING-domain E3 ubiquitin ligase, as a PARsylation-directed E3 ligase establishes a molecular paradigm that links tankyrase-dependent poly(ADP-ribosyl)ation to ubiquitylation and degradation of axin.
Journal ArticleDOI
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.
Koichi Kobayashi,Min Luo,Yue Zhang,David Wilkes,Gaoxiang Ge,Thomas Grieskamp,Chikaomi Yamada,Ting-Chun Liu,Guorui Huang,Craig T. Basson,Andreas Kispert,Daniel S. Greenspan,Thomas N. Sato +12 more
TL;DR: A function for sFRP2 is uncovered and a potential therapeutic application for sfrp2 antagonism in controlling fibrosis in the infarcted heart is found and this reduced level of fibrosis is accompanied by significantly improved cardiac function.
Journal ArticleDOI
Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination
Zhizhi Wang,Gregory A. Michaud,Zhihong Cheng,Yue Zhang,Thomas R. Hinds,Erkang Fan,Feng Cong,Wenqing Xu +7 more
TL;DR: The results suggest that protein poly(ADP-ribosyl)ation may be a general mechanism to target proteins for ubiquitination, since many WWE domain-containing proteins are known E3 ubiquitin ligases.