J
Jing Chen
Researcher at Onyx Pharmaceuticals
Publications - 3
Citations - 1624
Jing Chen is an academic researcher from Onyx Pharmaceuticals. The author has contributed to research in topics: RAC1 & Anti-apoptotic Ras signalling cascade. The author has an hindex of 3, co-authored 3 publications receiving 1610 citations.
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Journal ArticleDOI
An essential role for Rac in Ras transformation
TL;DR: It is shown that Ratl fibroblasts expressing activated Val-12 Racl (Racl with valine at residue 12) display all the hallmarks of malignant transformation and that Rac is essential for transformation by Ras, indicating that oncogenic Ras drives both the Rac and MAP-kinase pathways, which cooperate to cause transformation.
Journal ArticleDOI
A role for Rho in Ras transformation
TL;DR: It is concluded that Rho drives at least two separate pathways, one that induces stress fiber formation and another one that is important for transformation by oncogenic Ras.
Journal ArticleDOI
Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
Bela Anand-Apte,Bruce R. Zetter,Akila N. Viswanathan,Rong Guo Qiu,Jing Chen,Rosamaria Ruggieri,Marc Symons +6 more
TL;DR: Results indicate that directed cell migration mediated by different receptor classes in response to different ligands differentially utilizes the Rac and ERK pathways and suggest that Rac might play a critical role in pathological processes such as angiogenesis and metastasis.