J
Jing Chen
Researcher at Wuhan University
Publications - 44
Citations - 769
Jing Chen is an academic researcher from Wuhan University. The author has contributed to research in topics: Vascular smooth muscle & Neointimal hyperplasia. The author has an hindex of 13, co-authored 37 publications receiving 530 citations. Previous affiliations of Jing Chen include Georgia Institute of Technology.
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Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells.
TL;DR: The results indicate that miR-429 may not only be a useful biomarker of EMT in ovarian cancer, but also of potential therapeutic value in abating OC metastasis.
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LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A.
TL;DR: The present study revealed the critical role of the lncRNAH19/miR‐22‐3p/KDM3A pathway in MI and suggests that H19 may act as a potential biomarker and therapeutic target for MI.
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Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor
TL;DR: Inhibition of HMGB1 activity attenuated VSMCs activation and neointimal formation after carotid injury, which might represent a novel therapeutic strategy for vascular injury.
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Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway.
TL;DR: Nobiletin pre-treatment may alleviate MIRI probably via the attenuation of PI3K/AKT-mediated ERS-related myocardial apoptosis, as evidenced by echocardiographic evaluation results.
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Radioprotective 105 kDa protein attenuates ischemia/reperfusion-induced myocardial apoptosis and autophagy by inhibiting the activation of the TLR4/NF-κB signaling pathway in rats.
TL;DR: The results suggest that RP105 protects the myocardium against apoptosis and autophagy, and plays a cardioprotective role during I/R injury, most likely due to the inactivation of TLR4/NF-κB signaling pathway.