In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.

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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review.

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.

Biodegradable polymers have played an important role in the delivery of drugs in a controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one of the extensively researched synthetic biodegradable polymers due to its favorable properties. It is also known as a 'Smart Polymer' due to its stimuli sensitive behavior. A wide range of PLGA-based drug delivery systems have been reported for the treatment or diagnosis of various diseases and disorders. The present review provides an overview of the chemistry, physicochemical properties, biodegradation behavior, evaluation parameters and applications of PLGA in drug delivery. Different drug-polymer combinations developed into drug delivery or carrier systems are enumerated and discussed.

PLGA: a unique polymer for drug delivery

Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: A co-surfactant study

Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres.

Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method.

Development of gas phase controlled-release antimicrobial and antioxidant packaging film containing carvacrol loaded with HNT-4M（halloysite nanotubes etched by 4 mol/L hydrochloric acid）

Jing Xu

Papers

Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres.

Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method.

Development of gas phase controlled-release antimicrobial and antioxidant packaging film containing carvacrol loaded with HNT-4M（halloysite nanotubes etched by 4 mol/L hydrochloric acid）

Development of sodium alginate-based antioxidant and antibacterial bioactive films added with IRMOF-3/Carvacrol.

Synthesis of p-methoxybenzaldehyde/β-cyclodextrin inclusion complex and studies of its release properties in polylactic acid film