T
Thomas Kissel
Researcher at University of Marburg
Publications - 316
Citations - 31853
Thomas Kissel is an academic researcher from University of Marburg. The author has contributed to research in topics: Drug carrier & PLGA. The author has an hindex of 93, co-authored 316 publications receiving 30198 citations. Previous affiliations of Thomas Kissel include University of Utah & Shenyang Pharmaceutical University.
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In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.
TL;DR: The magnitude of the cytotoxic effects of all polymers were found to be time- and concentration dependent and the molecular weight as well as the cationic charge density of the polycations were confirmed as key parameters for the interaction with the cell membranes and consequently the cell damage.
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A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity
TL;DR: The LMW-PEI described here is a new, highly efficient, and non-cytotoxic vector with a favorable efficiency/toxicity profile for gene therapeutic applications.
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Chitosan-based formulations for delivery of DNA and siRNA.
Shirui Mao,Wei Sun,Thomas Kissel +2 more
TL;DR: Chitosan structure modification or additive incorporation is an effective way to improve the stability of the polyplex in biological fluids, enhance targeted cell delivery and facilitate endo-lysosomal release of the complex.
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Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives
TL;DR: Among the polycations presently used for gene delivery, poly(ethylene imine), PEI, takes a prominent position, due to its potential for endosomal escape, and derivatives of PEI currently under investigation for DNA and RNA delivery will be discussed.
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Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
TL;DR: This review will introduce the most important cationic polymers used as non-viral vectors for gene and oligonucleotide delivery and will summarize strategies for the targeting of these agents to cancer tissues.