J
Jingheng Zhou
Researcher at National Institutes of Health
Publications - 24
Citations - 1560
Jingheng Zhou is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Locus coeruleus. The author has an hindex of 12, co-authored 18 publications receiving 755 citations. Previous affiliations of Jingheng Zhou include Government of the United States of America & Peking University.
Papers
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Journal ArticleDOI
A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.
Fangmiao Sun,Jianzhi Zeng,Miao Jing,Miao Jing,Miao Jing,Jingheng Zhou,Jiesi Feng,Jiesi Feng,Jiesi Feng,Scott F. Owen,Yichen Luo,Funing Li,Huan Wang,Huan Wang,Takashi Yamaguchi,Zihao Yong,Yijing Gao,Wanling Peng,Lizhao Wang,Siyu Zhang,Jiulin Du,Dayu Lin,Min Xu,Anatol C. Kreitzer,Guohong Cui,Yulong Li,Yulong Li,Yulong Li +27 more
TL;DR: The development of genetically encoded GPCR-activation-based-DA (GRABDA) sensors enable spatiotemporally precise measurements of DA dynamics in a variety of model organisms while exhibiting complex behaviors.
Journal ArticleDOI
A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
Jiesi Feng,Jiesi Feng,Changmei Zhang,Julieta E. Lischinsky,Miao Jing,Jingheng Zhou,Huan Wang,Huan Wang,Yajun Zhang,Yajun Zhang,Ao Dong,Ao Dong,Zhaofa Wu,Zhaofa Wu,Hao Wu,Hao Wu,Hao Wu,Weiyu Chen,Peng Zhang,Jing Zou,S. Andrew Hires,J. Julius Zhu,Guohong Cui,Dayu Lin,Dayu Lin,Jiulin Du,Yulong Li +26 more
TL;DR: A family of GPCR activation-based NE (GRABNE) sensors with a 230% peak ΔF/F0 response to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second kinetics, and high specificity are developed.
Journal ArticleDOI
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo.
Fangmiao Sun,Fangmiao Sun,Jingheng Zhou,Bing Dai,Tongrui Qian,Tongrui Qian,Jianzhi Zeng,Jianzhi Zeng,Jianzhi Zeng,Xuelin Li,Xuelin Li,Yizhou Zhuo,Yizhou Zhuo,Yizhou Zhuo,Yajun Zhang,Yajun Zhang,Yajun Zhang,Yipan Wang,Yipan Wang,Cheng Qian,Cheng Qian,Cheng Qian,Ke Tan,Ke Tan,Jiesi Feng,Jiesi Feng,Jiesi Feng,Hui Dong,Hui Dong,Dayu Lin,Guohong Cui,Yulong Li,Yulong Li,Yulong Li +33 more
TL;DR: The GRABDA sensors resolve evoked DA release in mouse brain slices, detect evoked compartmental DA release from a single neuron in live flies, and report optogenetically elicited nigrostriatal DA release as well as mesoaccumbens dopaminergic activity during sexual behavior in freely behaving mice.
Posted ContentDOI
A genetically encoded fluorescent sensor for rapid and specific in vivo detection ofnorepinephrine
Jiesi Feng,Jiesi Feng,Changmei Zhang,Julieta E. Lischinsky,Julieta E. Lischinsky,Miao Jing,Miao Jing,Jingheng Zhou,Huan Wang,Huan Wang,Yajun Zhang,Yajun Zhang,Ao Dong,Ao Dong,Zhaofa Wu,Zhaofa Wu,Hao Wu,Hao Wu,Hao Wu,Weiyu Chen,Peng Zhang,Jing Zou,S. Andrew Hires,J. Julius Zhu,Guohong Cui,Dayu Lin,Dayu Lin,Jiulin Du,Yulong Li +28 more
TL;DR: A family of GPCR Activation-Based NE/Epi (GRABNE) sensors with a 230% peak ΔF/F0 response to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second rapid kinetics, high specificity to NE vs. dopamine are developed.
Journal ArticleDOI
Spectrally Resolved Fiber Photometry for Multi-component Analysis of Brain Circuits
TL;DR: A spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals found that the striatal direct and indirect pathways coordinately control the dynamics and fate of movement.