J
Jingrong Jean Cui
Researcher at Pfizer
Publications - 26
Citations - 1977
Jingrong Jean Cui is an academic researcher from Pfizer. The author has contributed to research in topics: Protein kinase A & Anaplastic lymphoma kinase. The author has an hindex of 14, co-authored 26 publications receiving 1897 citations. Previous affiliations of Jingrong Jean Cui include Polytechnic University of Bari.
Papers
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Journal ArticleDOI
An orally available small-molecule inhibitor of c-met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
Helen Y. Zou,Qiuhua Li,Joseph H. Lee,Maria E. Arango,Scott Rp McDonnell,Shinji Yamazaki,Tatiana B. Koudriakova,Gordon Alton,Jingrong Jean Cui,Pei Pei Kung,Nambu Mitchell David,Gerrit Los,Bender Steven Lee,Barbara Mroczkowski,James G. Christensen +14 more
TL;DR: The antitumor activity of PF-2341066 may be mediated by direct effects on tumor cell growth or survival as well as antiangiogenic mechanisms, and the therapeutic potential of targeting c-Met with selective small-molecule inhibitors for the treatment of human cancers is shown.
Journal Article
A Selective Small Molecule Inhibitor of c-Met Kinase Inhibits c-Met-Dependent Phenotypes in Vitro and Exhibits Cytoreductive Antitumor Activity in Vivo
James G. Christensen,Randall E. Schreck,Jon Burrows,Poonam Kuruganti,Emily Chan,Phuong Le,Jeffrey H. Chen,Xueyan Wang,Lany Ruslim,Robert A. Blake,Kenneth E. Lipson,John Ramphal,Steven Do,Jingrong Jean Cui,Julie M. Cherrington,Dirk B. Mendel +15 more
TL;DR: The feasibility of selectively targeting c-Met with ATP-competitive small-molecules with high selectivity is demonstrated and the therapeutic potential of targetingc-Met in human cancers is suggested.
Patent
Aminoheteroaryl compounds as protein kinase inhibitors
Jingrong Jean Cui,Dilip Bhumralkar,Botrous Iriny,Chu Ji Yu,Funk Lee Andrew,Hanau Cathleen Elizabeth,G. Davis Harris,Jia Lei,Johnson Joanne,Kolodziej Stephen A,Pei-Pei Kung,Xiaoyuan Li,J.-X. Lin,Meng Jerry Jialun,Nambu Mitchell David,Nelson Christopher G,Pairish Mason Alan,Hong Shen,Michelle Tran-Dubé,Walter Allison,Zhang Fang-Jie,Zhang Jennifer +21 more
TL;DR: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided in this article, where they have activity as protein kinase inhibitors, including as inhibitors of c-MET.
Patent
Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
Jingrong Jean Cui,Funk Lee Andrew,Jia Lei,Pei-Pei Kung,Meng Jerry Jialun,Nambu Mitchell David,Pairish Mason Alan,Hong Shen,Tran-Dube Michelle Bich +8 more
TL;DR: In this paper, an anti-met inhibitor of the c-Met protein kinase is described, which is useful in the treatment of abnormal cell growth disorders, such as cancers.
Journal ArticleDOI
Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor
Helen Y. Zou,Qiuhua Li,Joseph H. Lee,Maria E. Arango,Kristina Burgess,Ming Qiu,Lars D. Engstrom,Shinji Yamazaki,Max Parker,Sergei Timofeevski,Jingrong Jean Cui,Michele McTigue,Gerrit Los,Bender Steven Lee,Tod Smeal,James G. Christensen +15 more
TL;DR: Results show the use of highly selective inhibition of c-Met and provide insight toward targeting tumors exhibiting different mechanisms ofc-Met dysregulation, and also show potent antiangiogenic properties in vitro and in vivo.