Kenneth E. Lipson

TL;DR: The feasibility of selectively targeting c-Met with ATP-competitive small-molecules with high selectivity is demonstrated and the therapeutic potential of targetingc-Met in human cancers is suggested.

TL;DR: It is reported that the Met kinase inhibitor SU11274 differentially affects the kinase activity and subsequent signaling of various mutant forms of Met, and the basis for the sensitivity or resistance to SU 11274 is discussed in terms of the position of the mutations predicted from a homology model.

TL;DR: Results suggest a posttranscriptional component in the regulation of PCNA mRNA levels after serum stimulation but a transcriptional regulation by intron 4.

TL;DR: No TK hnRNA can be detected in truly quiescent human diploid fibroblasts, suggesting that in these cells, the TK gene is not transcribed in G0.

TL;DR: In this article, the pyrrole-indolinone inhibitors of Met tyrosine kinase have been found to inhibit HGF/SF-induced receptor phosphorylation in a dose-dependent manner.