Jinhua Zheng

TL;DR: It is found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation in tumor, and in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells.

TL;DR: Overall survival was significantly shorter in patients with high tumour and stromal M MP-2 and MMP-9 expression, and tended to be shorter in customers with low ColIV expression, which may be a useful technique for assessing prognoses in OTSCC patients.

TL;DR: Investigation of sonic hedgehog signaling pathway components in human oral squamous cell carcinoma found transcription factor Gli-1 of the SHH signaling pathway may be an important mediator of invasion and metastasis of OSCC through induced expression of MMP-9 and E-cadherin and may serve as a new prognostic marker.

TL;DR: Xenograft in vivo experiments using Balb/ca nude mice and MTT assays in vitro showed that ALA-LIU therapy significantly suppressed the proliferation of SAS cells, and administration of the ROS scavenger, N-acetylcysteine (NAC), suppressed ALA -LIU-induced apoptosis and the expression of mitochondria apoptosis-related proteins, which confirmed that the ALA's induced SAS cell apoptosis is through the generation of ROS.

TL;DR: ALA-mediated sonodynamic therapy (SDT) produced strong apoptotic effects on SAS cells, which were mainly related to the excessive intracellular ROS production followed by LPO increase and MMP decrease.