Yanhong Lv

TL;DR: It is found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation in tumor, and in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells.

TL;DR: Xenograft in vivo experiments using Balb/ca nude mice and MTT assays in vitro showed that ALA-LIU therapy significantly suppressed the proliferation of SAS cells, and administration of the ROS scavenger, N-acetylcysteine (NAC), suppressed ALA -LIU-induced apoptosis and the expression of mitochondria apoptosis-related proteins, which confirmed that the ALA's induced SAS cell apoptosis is through the generation of ROS.

TL;DR: The data suggest that PpIX-SDT suppress the proliferation of SAS cells via arresting cell cycle at G2/M phase and activating the extrinsic Fas-mediated membrane receptor pathway to induce apoptosis, which is regulated by p53.

TL;DR: Results suggest that scutellarin promotes angiogenesis and may form a basis for angiogenic therapy, and strongly induced MMP-2 activation and mRNA expression in cultured HUVECs in a concentration-dependent manner.

TL;DR: It is shown that scutellarin inhibits tumor cell proliferation and migration and regulates cell adhesion in OSCC cells; this may be closely related to up-regulation of E-cadherin and down- regulation of αvβ6 integrin.