J
Jinqian Liu
Researcher at Amgen
Publications - 25
Citations - 990
Jinqian Liu is an academic researcher from Amgen. The author has contributed to research in topics: Chemistry & Agonist. The author has an hindex of 14, co-authored 21 publications receiving 926 citations.
Papers
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Journal ArticleDOI
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4
TL;DR: High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.
Journal ArticleDOI
AMG 837: a potent, orally bioavailable GPR40 agonist.
Jonathan B. Houze,Liusheng Zhu,Ying Sun,Michelle Akerman,Wei Qiu,Alex Zhang,Rajiv Sharma,Michael J. Schmitt,Yingcai Wang,Jiwen Liu,Jinqian Liu,Julio C. Medina,Jeff D. Reagan,Jian Luo,George Tonn,Jane Zhang,Jenny Ying-Lin Lu,Michael Chen,Edwin Lopez,Kathy Nguyen,Yang Li,Liang Tang,Hui Tian,Steven J. Shuttleworth,Daniel C.-H. Lin +24 more
TL;DR: Optimize of a series of β-substituted phenylpropanoic acids led to the identification of (S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid (AMG 837) as a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
Journal ArticleDOI
SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase
Jay P. Powers,Derek E. Piper,Yang Li,Veronica Mayorga,John Anzola,James M Chen,Juan C. Jaen,Gary Lee,Jinqian Liu,M Greg Peterson,George Tonn,Qiuping Ye,Nigel Walker,Zhulun Wang +13 more
TL;DR: Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases.
Patent
Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
Michelle Akerman,Jonathan B. Houze,Daniel C.-H. Lin,Jiwen Liu,Jian Luo,Julio C. Medina,Wei Qiu,Reagan Jeffrey D,Michael J. Schmitt,Yingcai Wang,Rajiv Sharma,Stephen J. Shuttleworth,Ying Sun,Jian Zhang,Liusheng Zhu,Zhihua Ma,Jinqian Liu +16 more
TL;DR: In this article, the authors present compounds useful for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided.
Journal ArticleDOI
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Sean P. Brown,Paul John Dransfield,Marc Vimolratana,Xianyun Jiao,Liusheng Zhu,Vatee Pattaropong,Ying Sun,Jinqian Liu,Jian Luo,Jane Zhang,Simon Wong,Run Zhuang,Qi Guo,Frank Li,Julio C. Medina,Gayathri Swaminath,Daniel C.-H. Lin,Jonathan B. Houze +17 more
TL;DR: The optimization from the G PR40 partial agonist 1 to the structurally and pharmacologically distinct GPR40 full agonist AM-1638 (21) is presented and the improved in vivo efficacy that GPR 40 full agonists 21 exhibits in BDF/DIO mice as compared to partial agonists 1.