J
Jonathan B. Houze
Researcher at Amgen
Publications - 83
Citations - 3180
Jonathan B. Houze is an academic researcher from Amgen. The author has contributed to research in topics: Agonist & Triazole. The author has an hindex of 29, co-authored 83 publications receiving 2865 citations. Previous affiliations of Jonathan B. Houze include Stanford University & Japan Tobacco.
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Journal ArticleDOI
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Sean Caenepeel,Sean P. Brown,Brian Belmontes,Gordon Moody,Kathleen S. Keegan,Danny Chui,Douglas A. Whittington,Xin Huang,Leszek Poppe,Alan C. Cheng,Mario G. Cardozo,Jonathan B. Houze,Yunxiao Li,Brian Lucas,Nick A. Paras,Xianghong Wang,Joshua Taygerly,Marc Vimolratana,Manuel Zancanella,Liusheng Zhu,Elaina Cajulis,Tao Osgood,Jan Sun,Leah J. Damon,Regina K. Egan,Patricia Greninger,Joseph McClanaghan,Jia-Nan Gong,Jia-Nan Gong,Donia M Moujalled,Giovanna Pomilio,Pedro J. Beltran,Cyril H. Benes,Andrew W. Roberts,David C.S. Huang,David C.S. Huang,Andrew H. Wei,Jude Canon,Angela Coxon,Paul E. Hughes +39 more
TL;DR: AMG 176 is a potent, selective, and orally bioavailable MCL1 inhibitor that induces a rapid commitment to apoptosis in models of hematologic malignancies and the synergistic combination of AMG 176 and venetoclax is synergistic in acute myeloid leukemia (AML) tumor models and in primary patient samples at tolerated doses.
Journal ArticleDOI
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
Daqing Sun,Zhihong Li,Yosup Rew,Michael W. Gribble,Michael D. Bartberger,Hilary Plake Beck,Jude Canon,Ada Chen,Xiaoqi Chen,David Chow,Jeffrey Deignan,Jason Duquette,John Eksterowicz,Benjamin Fisher,Brian M. Fox,Jiasheng Fu,Ana Z. Gonzalez,Felix Gonzalez-Lopez de Turiso,Jonathan B. Houze,Xin Huang,Min Jiang,Lixia Jin,Frank Kayser,Jiwen Jim Liu,Mei-Chu Lo,Alexander M. Long,Brian Lucas,Lawrence R. McGee,Mcintosh Joel,Jeffrey T. Mihalic,Jonathan D. Oliner,Tao Osgood,Matthew L Peterson,Philip Roveto,Anne Y. Saiki,Paul L. Shaffer,Maria M. Toteva,Yingcai Wang,Yu Chung Wang,Sarah Wortman,Peter Yakowec,Xuelei Yan,Qiuping Ye,Dongyin Yu,Ming Yu,Xiaoning Zhao,Jing Zhou,Jiang Zhu,Steven H. Olson,Julio C. Medina +49 more
TL;DR: The discovery of AM-8553, a potent and selective piperidinone inhibitor of the MDM2-p53 interaction, led to the discovery of a one-carbon tethered sulfone which gave rise to substantial improvements in biochemical and cellular potency.
Journal ArticleDOI
The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol
Paul A. Wender,Neil F. Badham,Simon P. Conway,Paul E. Floreancig,Timothy E. Glass,Jonathan B. Houze,Nancy E. Krauss,Daesung Lee,Daniel G. Marquess,Paul L. McGrane,Wei Meng,Michael G. Natchus,Anthony J. Shuker,James C. Sutton,Richard E. Taylor +14 more
Journal ArticleDOI
The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor
Paul A. Wender,Neil F. Badham,Simon P. Conway,Paul E. Floreancig,Timothy E. Glass,Christian Gränicher,Jonathan B. Houze,Jan Jänichen,Daesung Lee,Daniel G. Marquess,Paul L. McGrane,Wei Meng,Thomas P. Mucciaro,Michel Mühlebach,Michael G. Natchus,Paulsen Holger,David B. Rawlins,Jeffrey Satkofsky,Anthony J. Shuker,James C. Sutton,Richard E. Taylor,Katsuhiko Tomooka +21 more
Journal ArticleDOI
AMG 837: a potent, orally bioavailable GPR40 agonist.
Jonathan B. Houze,Liusheng Zhu,Ying Sun,Michelle Akerman,Wei Qiu,Alex Zhang,Rajiv Sharma,Michael J. Schmitt,Yingcai Wang,Jiwen Liu,Jinqian Liu,Julio C. Medina,Jeff D. Reagan,Jian Luo,George Tonn,Jane Zhang,Jenny Ying-Lin Lu,Michael Chen,Edwin Lopez,Kathy Nguyen,Yang Li,Liang Tang,Hui Tian,Steven J. Shuttleworth,Daniel C.-H. Lin +24 more
TL;DR: Optimize of a series of β-substituted phenylpropanoic acids led to the identification of (S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid (AMG 837) as a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.