Jiu Deng

TL;DR: The physiological microenvironments in the liver, especially the cell composition and its specialized roles, are introduced, and the strategies to build a liver-on-a-chip via microfluidic technologies and its biomedical applications are summarized.

TL;DR: This cell lines derived liver model provides an alternative to investigate drug hepatotoxicity, drug-drug interaction and maintained synthetic and secretory functions, preserved cytochrome P450 1A1/2 and uridine diphosphate glucuronyltransferase enzymatic activities, as well as sensitivity of drug metabolism.

TL;DR: A demountable liver-on-chip device is developed for investigation of pathophysiological process of individual non-parenchymal cells in alcohol induced ALD and to understand the intercellular communication between different types of hepatic cells during ALD by measuring multiple biomarkers.

TL;DR: It is concluded that this microfluidic chip can be used to culture a single human ovarian follicle, which provides a useful tool to explore the hormonal changes and their interactions during folliculogenesis.

TL;DR: This study first reported the application of a liver chip in the hepatoprotective effect assessment and found that bifendatatum predominantly reduced alanine transaminase secretion, tiopronin predominantly reduced lactate dehydrogenase gland secretion, and glycyrrhizinate predominantly reduced aspartate transaminases secretion, which revealed the different mechanisms of these hepatop rotatedectant.