J
Jo Anne Welsch
Researcher at Children's Hospital Oakland Research Institute
Publications - 28
Citations - 3137
Jo Anne Welsch is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Neisseria meningitidis & Meningococcal vaccine. The author has an hindex of 22, co-authored 27 publications receiving 3040 citations. Previous affiliations of Jo Anne Welsch include United States Department of Agriculture & University of California, Berkeley.
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Journal ArticleDOI
A universal vaccine for serogroup B meningococcus
Marzia Monica Giuliani,Jeannette Adu-Bobie,Maurizio Comanducci,Beatrice Aricò,Silvana Savino,Laura Santini,Brunella Brunelli,Stefania Bambini,Alessia Biolchi,Barbara Capecchi,Elena Cartocci,Laura Ciucchi,Federica Di Marcello,Francesca Ferlicca,Barbara Galli,Enrico Luzzi,Vega Masignani,Davide Serruto,Daniele Veggi,Mario Contorni,Maurizio Morandi,Alessandro Bartalesi,Vanda Cinotti,Donatella Mannucci,Francesca Titta,Elisa Ovidi,Jo Anne Welsch,Dan M. Granoff,Rino Rappuoli,Mariagrazia Pizza +29 more
TL;DR: The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity and has the potential to conquer one of the most devastating diseases of childhood.
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Vaccination against Neisseria meningitidis Using Three Variants of the Lipoprotein GNA1870
Vega Masignani,Maurizio Comanducci,Marzia Monica Giuliani,Stefania Bambini,Jeannette Adu-Bobie,Beatrice Aricò,Brunella Brunelli,Alessandro Pieri,Laura Santini,Silvana Savino,Davide Serruto,David J. Litt,Simon Kroll,Jo Anne Welsch,Dan M. Granoff,Rino Rappuoli,Mariagrazia Pizza +16 more
TL;DR: GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that induces high levels of bactericidal antibodies, is discovered and is a top candidate for the development of a new vaccine against meningococcus.
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The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance
Guillermo Madico,Jo Anne Welsch,Lisa A. Lewis,Anne McNaughton,David H. Perlman,Catherine E. Costello,Jutamas Ngampasutadol,Ulrich Vogel,Dan M. Granoff,Sanjay Ram +9 more
TL;DR: The hypothesis that inhibiting the binding of a complement down-regulator protein to the neisserial surface by specific Ab may enhance intrinsic bactericidal activity of the Ab is supported, resulting in two distinct mechanisms of Ab-mediated vaccine efficacy.
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Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera
TL;DR: The species specificity of binding of human fH adds another mechanism toward the understanding of why N. meningitidis is strictly a human pathogen.
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Protective Activity of Monoclonal Antibodies to Genome-Derived Neisserial Antigen 1870, a Neisseria meningitidis Candidate Vaccine
TL;DR: Anti-GNA1870 variant 1 Abs are bactericidal and/or elicit C3b deposition and confer protection against bacteremia caused by encapsulated N. meningitidis strains expressing G NA1870 subvariant 1 proteins.