D
David H. Perlman
Researcher at Princeton University
Publications - 61
Citations - 3375
David H. Perlman is an academic researcher from Princeton University. The author has contributed to research in topics: Phosphorylation & Proteome. The author has an hindex of 29, co-authored 54 publications receiving 2967 citations. Previous affiliations of David H. Perlman include University of Calgary & Boston University.
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Journal ArticleDOI
The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance
Guillermo Madico,Jo Anne Welsch,Lisa A. Lewis,Anne McNaughton,David H. Perlman,Catherine E. Costello,Jutamas Ngampasutadol,Ulrich Vogel,Dan M. Granoff,Sanjay Ram +9 more
TL;DR: The hypothesis that inhibiting the binding of a complement down-regulator protein to the neisserial surface by specific Ab may enhance intrinsic bactericidal activity of the Ab is supported, resulting in two distinct mechanisms of Ab-mediated vaccine efficacy.
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Systems-level analysis of mechanisms regulating yeast metabolic flux.
Sean R. Hackett,Vito R T Zanotelli,Wenxin Xu,Jonathan Goya,Junyoung O. Park,David H. Perlman,Patrick A. Gibney,David Botstein,John D. Storey,Joshua D. Rabinowitz +9 more
TL;DR: In this paper, a systematic identification of meaningful metabolic enzyme regulation (SIMMER) was proposed, which can carry out regulatory inference at the level of single metabolic reactions by using cellular data.
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Software Tool for Researching Annotations of Proteins: Open-Source Protein Annotation Software with Data Visualization
TL;DR: The Software Tool for Researching Annotations of Proteins (STRAP), a user-friendly, open-source C# application that automatically obtains gene ontology (GO) terms associated with proteins in a proteomics results ID list using the freely accessible UniProtKB and EBI GOA databases.
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An oligotrophic deep-subsurface community dependent on syntrophy is dominated by sulfur-driven autotrophic denitrifiers
Maggie C. Y. Lau,Thomas L. Kieft,Olukayode Kuloyo,Borja Linage-Alvarez,Esta van Heerden,Melody R. Lindsay,Cara Magnabosco,Wei Wang,Jessica B. Wiggins,Ling Guo,David H. Perlman,Saw Kyin,Henry H. Shwe,Rachel L. Harris,Youmi Oh,Min Joo Yi,Roland Purtschert,Greg F. Slater,Shuhei Ono,Siwen Wei,Long Li,Long Li,Barbara Sherwood Lollar,Tullis C. Onstott +23 more
TL;DR: It is demonstrated that SLiMEs support taxonomically and metabolically diverse microorganisms, which, through developing syntrophic partnerships, overcome thermodynamic barriers imposed by the environmental conditions in the deep subsurface.
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The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development
Xiao Chen,John R. Bracht,Aaron David Goldman,Egor Dolzhenko,Derek M. Clay,Estienne C. Swart,David H. Perlman,Thomas G. Doak,Andrew Stuart,Chris T. Amemiya,Robert Sebra,Laura F. Landweber +11 more
TL;DR: The Oxytricha germline genome is reported and compared to the somatic genome to present a global view of its massive scale of genome rearrangements and provide a draft of a scrambled genome and a powerful model for studies of genome reshaping.