Joachim Kienast

TL;DR: In patients with angina pectoris, the levels of fibrinogen, von Willebrand factor antigen, and t-PA antigen are independent predictors of subsequent acute coronary syndromes and characterize patients at low risk for coronary events despite increased serum cholesterol levels.

TL;DR: The effects of VEGF on marrow stroma are studied, focusing on the secretion of interleukin-6 (IL-6), a potent growth factor for myeloma cells and an inhibitor of plasma cell apoptosis, which suggests paracrine interactions between myelomas and marrow stromal cells triggered by VEGf and IL-6.

TL;DR: Taken together, Flt3-ITD mutations induce factor-independent growth and leukemogenesis of 32D cells that are mediated by the Ras and STAT5 pathways.

TL;DR: There is evidence of increased microvessel density in the bone marrow of patients with AML, which supports the hypothesis of an important role of angiogenesis in AML and suggests that antiangiogenic therapy might constitute a novel strategy for the treatment of AML.

TL;DR: The adapted ISTH DIC score may identify patients with severe sepsis who potentially benefit from high‐dose AT treatment, and may result in a significant mortality reduction.