Reduction by magnetic nano-Fe(3)O(4)-Ni: a facile, simple and environmentally friendly hydrogen-transfer reaction that takes place over recyclable ferrite-nickel magnetic nanoparticles (Fe(3)O(4)-Ni) by using glycerol as hydrogen source allows aromatic amines and alcohols to be synthesized from the precursor nitroarenes and carbonyl compounds.

Regio‐ and Chemoselective Reduction of Nitroarenes and Carbonyl Compounds over Recyclable Magnetic Ferrite ? Nickel Nanoparticles (Fe3O4 ? Ni) by Using Glycerol as a Hydrogen Source

The review deals with commercially available organic dyes possessing large Stokes shifts and their applications as fluorescent labels in optical microscopy based on stimulated emission depletion (STED). STED microscopy breaks Abbe's diffraction barrier and provides optical resolution beyond the diffraction limit. STED microscopy is non-invasive and requires photostable fluorescent markers attached to biomolecules or other objects of interest. Up to now, in most biology-related STED experiments, bright and photoresistant dyes with small Stokes shifts of 20–40 nm were used. The rapid progress in STED microscopy showed that organic fluorophores possessing large Stokes shifts are indispensable in multi-color super-resolution techniques. The ultimate result of the imaging relies on the optimal combination of a dye, the bio-conjugation procedure and the performance of the optical microscope. Modern bioconjugation methods, basics of STED microscopy, as well as structures and spectral properties of the presently available fluorescent markers are reviewed and discussed. In particular, the spectral properties of the commercial dyes are tabulated and correlated with the available depletion wavelengths found in STED microscopes produced by LEICA Microsytems, Abberior Instruments and Picoquant GmbH.

/pdf/fluorescent-dyes-with-large-stokes-shifts-for-super-3b7lapkwpk.pdf

Fluorescent dyes with large Stokes shifts for super-resolution optical microscopy of biological objects: a review

Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.

https://www.mdpi.com/2076-3417/9/15/3139/pdf

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Regioselective palladium-catalyzed olefination of coumarins via aerobic oxidative Heck reactions

A facile, simple and environmentally friendly Fe3O4–cysteine MNP was synthesized without any additive or additional source of linkers. Fe3O4–cysteine MNPs were successfully used for the synthesis of β-amino carbonyl and hydroquinoline compounds, which were obtained in excellent yields via multicomponent reactions. Magnetic organocatalysts can be easily recovered by simple magnetic decantation and their catalytic activity remains unaltered after 9 consecutive cycles, making them environmentally friendly and widely applicable due to their efficiency, ease of handling, and cost effectiveness.

A facile synthesis of cysteine–ferrite magnetic nanoparticles for application in multicomponent reactions—a sustainable protocol

http://dspace.uevora.pt/rdpc/bitstream/10174/3465/1/Artigo%20Org%20Letters.pdf

Convenient synthesis of 3-vinyl and 3-styryl coumarins.

The cytotoxicity-guided study of the dichloromethane and ethanol extracts of Thymus mastichina L. using the HCT colon cancer cell line allowed the identification of nine compounds, sakuranetin (1), sterubin (2), oleanolic acid (3), ursolic acid (4), lutein (5), beta-sitosterol (6), rosmarinic acid (7), 6-hydroxyluteolin-7-O-beta-glucopyranoside (8), and 6-hydroxyapigenin-7-O-beta-glucopyranoside (9). All compounds were tested for their cytotoxicity against the HCT colon cancer cell line. Compound 4 showed cytotoxicity with GI50 value of 6.8 microg/mL. A fraction composed of a mixture (1:1) of triterpenoid acids 3 and 4 displayed improved cytotoxicity with a GI50 of 2.8 microg/mL suggesting a synergistic behavior. This is the first report on the chemical constituents of Thymus mastichina L. based on structural assignments by spectroscopic analysis. The presence of these constituents identified by colon cancer cytotoxicity-guided activity indicates that extracts of T. mastichina L. may have a protective effect against colon cancers.

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1200701120

Thymus mastichina: chemical constituents and their anti-cancer activity.

Aziridination and unpredicted homologation reaction of N-sulfonylimines were achieved easily with a very simple, rapid and mild procedure through the use of diazomethane without the presence of any catalyst. The method represents an attractive alternative to metal-catalyzed processes.

Catalyst-free aziridination and unexpected homologation of aziridines from imines

The reaction of 2-hydroxyaldehydes with 3-butenoic acid proceeds best via 3 steps in a one-pot manner to afford 3-vinylcoumarins.

Convenient Synthesis of 3‐Vinyl and 3‐Styryl Coumarins.

Aziridination and homologation reaction of N-sulfonylimines are easily achieved by the present new, very simple, rapid and mild procedure using diazomethane as carbene source without any catalyst.

Joana Gordo

Papers

Convenient synthesis of 3-vinyl and 3-styryl coumarins.

Thymus mastichina: chemical constituents and their anti-cancer activity.

Catalyst-free aziridination and unexpected homologation of aziridines from imines

Convenient Synthesis of 3‐Vinyl and 3‐Styryl Coumarins.

Catalyst‐Free Aziridination and Unexpected Homologation of Aziridines from Imines.