J
Joana M. Xavier
Researcher at University of the Algarve
Publications - 32
Citations - 1208
Joana M. Xavier is an academic researcher from University of the Algarve. The author has contributed to research in topics: Genome-wide association study & Cellular differentiation. The author has an hindex of 18, co-authored 30 publications receiving 1089 citations. Previous affiliations of Joana M. Xavier include Instituto Gulbenkian de Ciência & University of Lisbon.
Papers
More filters
Journal Article
The role of p53 in apoptosis.
TL;DR: It is suggested that the finely tuned, complex control of p53 by Mdm-2 (mouse double minute-2, an oncoprotein) is a key step in UDCA modulation of p52-triggered apoptosis, with particular emphasis on potential benefits of UDCA.
Journal ArticleDOI
Association study of IL10 and IL23R–IL12RB2 in Iranian patients with Behçet's disease
Joana M. Xavier,Farhad Shahram,Fereydoun Davatchi,Alexandra Rosa,Jorge Crespo,Bahar Sadeghi Abdollahi,Abdolhadi Nadji,Gorete Jesus,Filipe Barcelos,José Vaz Patto,Niloofar Mojarad Shafiee,Fahmida Ghaderibarim,Sofia A. Oliveira,Sofia A. Oliveira +13 more
TL;DR: Results of meta-analyses combined with data from other populations further confirmed the role of rs1518111, rs17375018, rs7517847, and rs924080 in the risk of BD, but no epistatic interactions between IL10 and IL23R-IL12RB2 were detected.
Journal ArticleDOI
Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation
Márcia M. Aranha,Daniela M. Santos,Joana M. Xavier,Walter C. Low,Clifford J. Steer,Susana Solá,Cecília M. P. Rodrigues +6 more
TL;DR: The identification ofmiR-16, let-7a and miR-34a, whose expression patterns are conserved in mouse, rat and human neural differentiation, implicates these specific miRNAs in mammalian neuronal development and provides new insights into the regulation of neuronal differentiation by apoptosis-associated miRNas.
Journal ArticleDOI
MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins
Ana L. Morgado,Joana M. Xavier,Pedro A. Dionísio,Maria F. Ribeiro,Raquel B. Dias,Ana M. Sebastião,Susana Solá,Cecília M. P. Rodrigues +7 more
TL;DR: A novel role for miR-34a regulation of NSC differentiation is demonstrated, where miR -34a downregulation and subsequent increase of Syt1 and Atg9a appear to be crucial for neurogenesis progression.
Journal ArticleDOI
FUT2: filling the gap between genes and environment in Behçet's disease?
Joana M. Xavier,Joana M. Xavier,Farhad Shahram,Inês Sousa,Inês Sousa,Fereydoun Davatchi,Mafalda Matos,Mafalda Matos,Bahar Sadeghi Abdollahi,João Sobral,João Sobral,Abdolhadi Nadji,Manuela Oliveira,Fahmida Ghaderibarim,Niloofar Mojarad Shafiee,Sofia A. Oliveira,Sofia A. Oliveira +16 more
TL;DR: A genome-wide association study using DNA pooling suggests for the first time a putative link between a specific gene and environment in the aetiopathogenesis of BD.