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Walter C. Low
Researcher at University of Minnesota
Publications - 245
Citations - 14913
Walter C. Low is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Stem cell. The author has an hindex of 48, co-authored 234 publications receiving 14034 citations. Previous affiliations of Walter C. Low include University of Vermont & University of Michigan.
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Journal ArticleDOI
Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang,Balkrishna N. Jahagirdar,R. Lee Reinhardt,Robert E. Schwartz,C. Dirk Keene,Xilma R. Ortiz-Gonzalez,Morayma Reyes,Todd Lenvik,Troy C. Lund,Mark Blackstad,Jingbo Du,Sara Aldrich,Aaron Lisberg,Walter C. Low,David A. Largaespada,Catherine M. Verfaillie +15 more
TL;DR: It is reported here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into meschymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.
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Human Bone Marrow Stem Cells Exhibit Neural Phenotypes and Ameliorate Neurological Deficits after Grafting into the Ischemic Brain of Rats
TL;DR: It is unlikely that the functional recovery observed by the ischemic rats with human MSC grafts was mediated by the integration of new "neuronal" cells into the circuitry of the host brain, which could have upregulated host brain plasticity in response to experimental stroke.
Journal ArticleDOI
Non-ATG–initiated translation directed by microsatellite expansions
Tao Zu,Brian Gibbens,Noelle S. Doty,Mário Gomes-Pereira,Aline Huguet,Matthew D. Stone,Jamie M. Margolis,Mark Peterson,Todd W. Markowski,Melissa Ingram,Zhenhong Nan,Colleen L. Forster,Walter C. Low,Benedikt Schoser,Nikunj V. Somia,H. Brent Clark,Stephen C. Schmechel,Peter B. Bitterman,Geneviève Gourdon,Maurice S. Swanson,Melinda L. Moseley,Laura P.W. Ranum +21 more
TL;DR: It is shown that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established mouse models and human tissue.
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Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions
Walter C. Low,Walter C. Low,P. R. Lewis,S. Terri Bunch,Stephen B. Dunnett,Stephen R. Thomas,Susan D. Iversen,Anders Björklund,Ulf Stenevi +8 more
TL;DR: Evidence is provided that a reinnervation of the hippocampal formation from cholinergic-rich septal transplants is functional in terms of the physiology of neural connectivity and that the newly formed connections can interact with an intrinsic afferent system, the perforant path.
Journal ArticleDOI
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
C. Dirk Keene,Cecília M. P. Rodrigues,Cecília M. P. Rodrigues,Tacjana Eich,Manik Chhabra,Clifford J. Steer,Walter C. Low +6 more
TL;DR: TUDCA is a nontoxic, endogenously produced hydrophilic bile acid that is neuroprotective in a transgenic mouse model of HD and, therefore, may provide a novel and effective treatment in patients with HD.