Showing papers by "João P. G. L. M. Rodrigues published in 2022"
TL;DR: In this paper , the authors analyzed the evolution of the S protein as recorded in 276,712 samples collected before the start of vaccination efforts and found that most variants of SARS-CoV-2 variants with substitutions on the spike (S) protein increase the risk of immune evasion and cross-species transmission.
1 citations
20 Oct 2022
TL;DR: In this article , the potential of DNA regions to form hairpin/cruciform structures is studied. But, the potential to form these structures is very heterogeneous across different human genome regions and different regions display strikingly different patterns of enrichment of concentration depending on inverted repeat spacing.
Abstract: Hairpin/cruciform structures, as well as other non-B DNA structures, are important regulators for biological processes and gene function. The formation of these structures require that the DNA sequence contains adequately spaced inverted repeats. To study the potential of DNA regions to form hairpin/cruciform structures, we developed a new procedure to analyse the variation of the concentration of occurrence of inverted repeats at different spacings along the human genome. We apply the method to the human genome and identify regions with atypical high concentration of inverted repeats when compared to a control scenario based on a Markov model of order 7. We found that the potential to form hairpin/cruciform structures is very heterogeneous across different human genome regions. Also, different regions display strikingly different patterns of enrichment of concentration depending on inverted repeats spacing.